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All patients fulfilled the classification criteria for SSc and had a disease duration less than five years at enrollment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A cohort of 427 patients, consisting of 124 Hispanic, 220 non\u2010Hispanic White, and 83 non\u2010Hispanic Black participants were examined. At enrollment, Hispanic patients were significantly younger but had longer disease duration, higher frequency of U1\u2010RNP positivity as well as concurrent systemic lupus erythematosus (SLE) diagnosis, and lower income and educational levels in comparison to non\u2010Hispanic White patients. Compared with non\u2010Hispanic Black patients, Hispanic patients had more frequently limited cutaneous involvement and anticentromere antibodies.<\/jats:p><jats:p>In the longitudinal analysis, Hispanic patients had significantly lower forced vital capacity percents predicted (point estimate, \u22129.3%; <jats:italic>P<\/jats:italic> &lt; 0.001) than non\u2010Hispanic White but not Black patients. Hispanic patients had similar longitudinal modified Rodnan Skin Scores like non\u2010Hispanic White patients but lower measurements than non\u2010Hispanic Black patients (point estimate, \u22123.2; <jats:italic>P<\/jats:italic> = 0.029). Hispanic patients had significantly higher serially obtained perceived functional disability scores than White patients (point estimate, 0.29; <jats:italic>P<\/jats:italic> &lt; 0.001). Hispanic patients also had higher mortality rates than White Americans even after adjustment for age, gender, and socioeconomic statuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hispanic patients have higher likelihood of having U1\u2010RNP positivity and SLE overlap, more severe restrictive lung disease, as well as higher rate of mortality than non\u2010Hispanic White patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25300","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:34:25Z","timestamp":1705278865000},"page":"768-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Prospective Observational Study of Disease Severity and Mortality in Hispanic American Patients With Systemic 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Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Theodore","sequence":"additional","affiliation":[{"name":"McGovern Medical School at the University of Texas Health Science Center at Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Pedroza","sequence":"additional","affiliation":[{"name":"McGovern Medical School at the University of Texas Health Science Center at Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5070-2535","authenticated-orcid":false,"given":"Maureen D.","family":"Mayes","sequence":"additional","affiliation":[{"name":"McGovern Medical School at the University of Texas Health Science Center at Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-9978","authenticated-orcid":false,"given":"Shervin","family":"Assassi","sequence":"additional","affiliation":[{"name":"McGovern Medical 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