{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T11:25:08Z","timestamp":1793359508659,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Our objective was to evaluate the ability of Systemic Lupus Erythematosus Disease Activity Score (SLE\u2010DAS) remission and low disease activity (LDA) to discriminate active drug from placebo and to discriminate outcomes in the patients\u2019 perspective (health\u2010related quality of life [HR\u2010QoL]) in SLE trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a post hoc analysis of the pooled Belimumab in Subjects With SLE (BLISS)\u201052 (NCT00424476) and BLISS\u201076 (NCT00410384) trials data. SLE\u2010DAS remission and LDA attainment and discrimination between belimumab and placebo at 52\u2009weeks were compared using chi\u2010square tests. At week 52, 36\u2010item Short Form Health Survey (SF\u201036) and Functional Assessment of Chronic Illness Therapy Fatigue (FACIT\u2010F) scores were compared between patients attaining SLE\u2010DAS remission versus nonremission and SLE\u2010DAS LDA versus non\u2010LDA using the <jats:italic>t<\/jats:italic>\u2010test and Mann\u2010Whitney test. Mean changes from week 0 to 52 in SF\u201036 and FACIT\u2010F scores were compared between groups using multivariate regression analysis adjusted for baseline scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At week 52, significantly more patients attained SLE\u2010DAS LDA taking belimumab 1 mg\/kg (17.9% vs 13.0%; <jats:italic>P<\/jats:italic> =\u20090.023; odds ratio [OR] 1.459; relative risk [RR] 1.377; number needed to treat [NNT] 20.4) and 10 mg\/kg (21.7% vs 13.0%; <jats:italic>P<\/jats:italic> &lt;\u20090.001; OR 1.853; RR 1.668; NNT 11.5) compared with placebo. Likewise, more patients attained SLE\u2010DAS remission taking belimumab 10 mg\/kg compared to placebo (14.7% vs 10.1%; <jats:italic>P<\/jats:italic> =\u20090.019; OR 1.532; RR 1.454; NNT 21.7). At week 52, patients attaining SLE\u2010DAS remission and LDA presented higher SF\u201036 domain and summary scores (all <jats:italic>P<\/jats:italic> &lt;\u20090.001) and FACIT\u2010F scores (both <jats:italic>P<\/jats:italic> &lt;\u20090.001). Mean improvements from baseline in SF\u201036 and FACIT\u2010F scores were significantly higher in patients achieving SLE\u2010DAS remission and LDA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SLE\u2010DAS remission and LDA showed discriminant ability for identifying patients receiving active drug in SLE clinical trials. Attainment of these SLE\u2010DAS targets are associated with better HR\u2010QoL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25305","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T01:54:27Z","timestamp":1705974867000},"page":"788-795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Systemic Lupus Erythematosus Disease Activity Score Remission and Low Disease Activity States Discriminate Drug From Placebo and Better <scp>Health\u2010Related<\/scp> Quality of Life"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3136-0722","authenticated-orcid":false,"given":"Diogo","family":"Jesus","sequence":"first","affiliation":[{"name":"Centro Hospitalar de Leiria Leiria, Portugal, and Faculty of Health Sciences, University of Beira Interior  Covilh\u00e1 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