{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:52:04Z","timestamp":1788609124244,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001203","name":"GlaxoSmithKline Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000940","name":"Arthritis Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000940","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP\u20101126370"],"award-info":[{"award-number":["APP\u20101126370"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP\u20101197169"],"award-info":[{"award-number":["APP\u20101197169"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer AG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the epidemiology, associations, and impact of inflammatory arthritis (IA) in systemic sclerosis (SSc).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with SSc prospectively enrolled in the Australian Scleroderma Cohort Study were included. IA was defined clinically as the presence of synovitis on examination. Logistic regression was used to determine the associations of IA with SSc manifestations and serological parameters. Patient\u2010reported outcome measures were used to capture physical function and health\u2010related quality of life (HRQoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IA was a common SSc manifestation affecting one\u2010third (33.3%) of patients over a median follow\u2010up of 4.3 (1.7\u20138.4) years. Associations of IA included diffuse SSc (odds ratio [OR] 1.33, 95% confidence interval [95% CI] 1.01\u20131.74, <jats:italic>P<\/jats:italic> =\u20090.042), concurrent musculoskeletal manifestations (joint contractures and tendon friction rubs, OR 1.70, 95% CI 1.34\u20132.15, <jats:italic>P<\/jats:italic> &lt;\u20090.001); myositis (OR 2.11, 95% CI 1.39\u20133.20, <jats:italic>P<\/jats:italic> &lt;\u20090.001), and sicca symptoms (OR 1.57, 95% CI 1.14\u20132.16, <jats:italic>P<\/jats:italic> =\u20090.006), whereas IA was negatively associated with pulmonary arterial hypertension (OR 0.52, 95% CI 0.35\u20130.78, <jats:italic>P<\/jats:italic> =\u20090.002). Neither the presence of rheumatoid factor nor U1\u2009small nuclear RNP were associated with IA (OR 1.13, 95% CI 0.88\u20131.44, <jats:italic>P<\/jats:italic> =\u20090.331, OR 1.46, 95% CI 0.89\u20132.39, <jats:italic>P<\/jats:italic> =\u20090.129 respectively). Positive anticyclic citrullinated protein antibodies, although at low frequency, were more common in those with IA compared with those without IA (7.5% vs 1.5%, <jats:italic>P<\/jats:italic> &lt;\u20090.001). IA was associated with significantly lower HRQoL score (<jats:italic>P<\/jats:italic> &lt;\u20090.001) and more physical disability than in those without IA (<jats:italic>P<\/jats:italic> &lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IA is a common disease manifestation that is more frquently seen in diffuse disease. IA is associated with poor HRQoL and physical disability. Further research is needed into the effective management of IA in SSc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25311","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T01:00:30Z","timestamp":1707354030000},"page":"760-767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Inflammatory Arthritis in Systemic Sclerosis: Its Epidemiology, Associations, and Morbidity"],"prefix":"10.1002","volume":"76","author":[{"given":"Eric","family":"Schwender","sequence":"first","affiliation":[{"name":"Royal College of Surgeons  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Hansen","sequence":"additional","affiliation":[{"name":"The University of Melbourne at St Vincent's Hospital  Melbourne Victoria 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Sahhar","sequence":"additional","affiliation":[{"name":"Monash University, Clayton and Monash Health  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene","family":"Ngian","sequence":"additional","affiliation":[{"name":"Monash University, Clayton and Monash Health  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Host","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital  Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-7438","authenticated-orcid":false,"given":"Gabor","family":"Major","sequence":"additional","affiliation":[{"name":"Royal Newcastle Centre  New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandana","family":"Nikpour","sequence":"additional","affiliation":[{"name":"The University of Melbourne at St Vincent's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3840-3967","authenticated-orcid":false,"given":"Kathleen","family":"Morrisroe","sequence":"additional","affiliation":[{"name":"The University of Melbourne at St Vincent's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2015.04.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13203"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2015.04.011"},{"key":"e_1_2_7_5_1","first-page":"157","article-title":"Quality of 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