{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:46:46Z","timestamp":1782283606366,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32\u2010AR\u2010007258"],"award-info":[{"award-number":["T32\u2010AR\u2010007258"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K23\u2010AR\u2010081425"],"award-info":[{"award-number":["K23\u2010AR\u2010081425"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P50\u2010AR\u2010060772"],"award-info":[{"award-number":["P50\u2010AR\u2010060772"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01\u2010AR\u2010065944"],"award-info":[{"award-number":["R01\u2010AR\u2010065944"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>There is surging interest in using dual\u2010energy computed tomography (DECT) to identify cardiovascular monosodium urate (MSU) deposits in patients with gout. We sought to examine the prevalence and characterization of cardiovascular DECT artifacts using non\u2013electrocardiogram (EKG)\u2010gated DECT pulmonary angiograms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed non\u2013EKG\u2010gated DECT pulmonary angiograms performed on patients with and without gout at a single academic center. We noted the presence and locations of vascular green colorization using the default postprocessing two\u2010material decomposition algorithm for MSU. The high\u2010 and low\u2010energy grayscale images and advanced DECT measurements were used to determine whether they were true findings or artifacts. We classified artifacts into five categories: streak, contrast medium mixing, misregistration due to motion, foreign body, and noise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our study included CT scans from 48 patients with gout and 48 age\u2010 and sex\u2010matched controls. The majority of patients were male with a mean age of 67 years. Two independent observers attributed all areas of vascular green colorization to artifacts. The most common types of artifacts were streak (56% vs 57% between patients and controls, respectively) and contrast medium mixing (51% vs 65%, respectively). Whereas some of the default DECT measurements of cardiovascular green colorization were consistent with values reported for subcutaneous tophi, advanced DECT measurements were not consistent with that of tophi.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Artifacts that could be misconstrued as cardiovascular MSU deposits were commonly identified in patients with and without gout on non\u2013EKG\u2010gated DECT pulmonary angiograms. These artifacts can inform future vascular DECT studies on patients with gout to minimize false\u2010positive findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25312","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T05:11:23Z","timestamp":1707282683000},"page":"953-963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Frequently Encountered Artifacts in the Application of <scp>Dual\u2010Energy<\/scp> Computed Tomography to Cardiovascular Imaging for Urate Crystals in Gout: A <scp>Matched\u2010Control<\/scp> Study"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7557-3303","authenticated-orcid":false,"given":"Chio","family":"Yokose","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital  Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling Ellis","family":"Eide","sequence":"additional","affiliation":[{"name":"National University Hospital of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian A.","family":"Huber","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School, Boston, and University Hospital Zurich and University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Joseph","family":"Simeone","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School  Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian B.","family":"Ghoshhajra","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Shojania","sequence":"additional","affiliation":[{"name":"Vancouver General Hospital and Arthritis Research Canada  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savvas","family":"Nicolaou","sequence":"additional","affiliation":[{"name":"Vancouver General Hospital  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8444-8504","authenticated-orcid":false,"given":"Fabio","family":"Becce","sequence":"additional","affiliation":[{"name":"Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2862-0442","authenticated-orcid":false,"given":"Hyon K.","family":"Choi","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001124"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.09.033"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.703389"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283257b96"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.10.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-005308"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01621-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb33318.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12051240"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-012-0301-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.099713"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200976"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016151109"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11102485"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.3201"},{"issue":"2","key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1136\/annrheumdis-2019-eular.3547","article-title":"THU0598 role of dual\u2010energy ct as a screening tool for coronary gout","volume":"78","author":"Abdellatif W","year":"2019","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"e_1_2_6_18_1","article-title":"Abstract 11821: detection of uric acid crystals in the vasculature of patients with gout using dual\u2010energy computed tomography","volume":"70","author":"Barazani S CW","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000001222"},{"key":"e_1_2_6_20_1","first-page":"552","article-title":"A security architecture for query tools used to access large biomedical databases","author":"Murphy SN","year":"2002","journal-title":"Proc AMIA Symp"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2021.06.009"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390820"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.11396"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v12.i8.184"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2022.152064"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211343"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40848"}],"container-title":["Arthritis Care &amp; 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