{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:28:42Z","timestamp":1789673322677,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1197169"],"award-info":[{"award-number":["APP1197169"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GTN1\u2010176538"],"award-info":[{"award-number":["GTN1\u2010176538"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023332","name":"Scleroderma Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000940","name":"Arthritis Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000940","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GSK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"BMS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Patients with pulmonary arterial hypertension (PAH) may be stratified as low, intermediate, or high risk of 1\u2010year mortality. In 2022, the European Society of Cardiology (ESC) updated and simplified its risk stratification tool, based on three variables: World Health Organization functional class, serum N\u2010terminal pro\u2010brain type natriuretic peptide and six\u2010minute walk distance, applied at follow\u2010up visits, intended to guide therapy over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We applied the 2022 ESC risk assessment tool at baseline and follow\u2010up (within 2 years) to a multinational incident cohort of systemic sclerosis\u2010associated PAH (SSc\u2010PAH). Kaplan\u2010Meier curves, Cox hazards regression, and accelerated failure time models were used to evaluate survival by risk score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline (n = 260), the majority of SSc\u2010PAH (72.2%) were graded as intermediate risk of death according to the 2022 tool. At follow\u2010up, according to 2022 tool, half (55.5%) of the cohort were classified as low or intermediate\u2010low risk. The 2022 risk model at follow\u2010up was able to differentiate survival between risk strata. All three individual parameters (World Health Organization functional class, N\u2010terminal pro\u2010brain type natriuretic peptide, six\u2010minute walk distance) were significantly associated with mortality at baseline and\/or follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 2022 ESC risk assessment strategy applied at baseline and follow\u2010up predicts survival in SSc\u2010PAH. Treatment decisions for SSc\u2010PAH should include risk assessments, aiming to achieve low\u2010risk status according to the 2022 ESC guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25328","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:29:41Z","timestamp":1711326581000},"page":"973-983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the European Society of Cardiology Risk Assessment Score in Incident Systemic <scp>Sclerosis\u2010Associated<\/scp> Pulmonary Arterial Hypertension"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4973-8212","authenticated-orcid":false,"given":"Zoe","family":"Brown","sequence":"first","affiliation":[{"name":"The University of Melbourne at St. Vincent's Hospital and St. Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Hansen","sequence":"additional","affiliation":[{"name":"St. Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Stevens","sequence":"additional","affiliation":[{"name":"St. Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nava","family":"Ferdowsi","sequence":"additional","affiliation":[{"name":"St. Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4636-729X","authenticated-orcid":false,"given":"Laura","family":"Ross","sequence":"additional","affiliation":[{"name":"The University of Melbourne at St. Vincent's Hospital and St. Vincent's Hospital Melbourne  Melbourne Victoria Australia"},{"name":"St. Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alannah","family":"Quinlivan","sequence":"additional","affiliation":[{"name":"The University of Melbourne at St. Vincent's Hospital and St. Vincent's Hospital Melbourne  Melbourne Victoria Australia"},{"name":"St. Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Sahhar","sequence":"additional","affiliation":[{"name":"Monash Health and Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene\u2010Siew","family":"Ngian","sequence":"additional","affiliation":[{"name":"Monash Health and Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Apostolopoulos","sequence":"additional","affiliation":[{"name":"Monash Health and Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer G.","family":"Walker","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia, University of Adelaide, North Adelaide, South Australia, Australia, and Flinders Medical Centre  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Proudman","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia, and University of Adelaide  North Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gim Gee","family":"Teng","sequence":"additional","affiliation":[{"name":"Alexandra Hospital, National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea H. L.","family":"Low","sequence":"additional","affiliation":[{"name":"Singapore General Hospital and Duke National University of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3840-3967","authenticated-orcid":false,"given":"Kathleen","family":"Morrisroe","sequence":"additional","affiliation":[{"name":"The University of Melbourne at St. Vincent's Hospital and St. Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandana","family":"Nikpour","sequence":"additional","affiliation":[{"name":"The University of Melbourne at St. Vincent's Hospital and St. Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 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criteria for systemic sclerosis: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"72","author":"Van den Hoogen F","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.5301\/jsrd.5000256","article-title":"What have multicentre registries across the world taught us about the disease features of systemic sclerosis?","volume":"2","author":"Proudman SM","year":"2017","journal-title":"J Scleroderma Relat Disord"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.semarthrit.2019.11.005","article-title":"Mortality and hospitalization outcomes of interstitial lung disease and pulmonary hypertension in the Singapore systemic sclerosis cohort","volume":"50","author":"Noviani M","year":"2020","journal-title":"Semin Arthritis 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Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.25328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T14:37:51Z","timestamp":1759415871000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.25328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/acr.25328"],"URL":"https:\/\/doi.org\/10.1002\/acr.25328","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]},"assertion":[{"value":"2023-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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