{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:13:09Z","timestamp":1782299589768,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015866","name":"Hezkuntza, Hizkuntza Politika Eta Kultura Saila, Eusko Jaurlaritza","doi-asserted-by":"publisher","award":["Research grant IT 1512\u201022"],"award-info":[{"award-number":["Research grant IT 1512\u201022"]}],"id":[{"id":"10.13039\/100015866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020230","name":"Consejer\u00eda de Transformaci\u00f3n Econ\u00f3mica, Industria, Conocimiento y Universidades","doi-asserted-by":"publisher","award":["Research grant PREDOC\u201000826"],"award-info":[{"award-number":["Research grant PREDOC\u201000826"]}],"id":[{"id":"10.13039\/100020230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to analyze the effect of methylprednisolone pulses (MP), given during the first year after the diagnosis of systemic lupus erythematosus (SLE), in achieving prolonged remission according to the degree of lupus activity at presentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an observational study of routine clinical care data from the Lupus\u2010Cruces\u2010Bordeaux cohort. The end point was prolonged remission (ie, during five consecutive yearly visits). The effect of MP on remission during the first year was analyzed in the whole cohort and according to the baseline Systemic Lupus Erythematosus Disease Activity Index 2000 score: &lt;6, 6 to 12, and &gt;12, reflecting mild, moderate, and severe activity, respectively. For adjustment, logistic regression with propensity score (PS) and other therapeutic covariates was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred thirty\u2010three patients were included. Prolonged remission was achieved by 132 patients (57%). MP were associated with prolonged remission (PS\u2010adjusted odds ratio [OR] 2.50, 95% confidence interval [CI] 1.04\u2013623, <jats:italic>P<\/jats:italic> = 0.042). A strong clinical effect was seen among patients with moderate (adjusted OR 5.28, 95% CI 1.27\u201321.97, <jats:italic>P<\/jats:italic> = 0.022) and moderate\u2010severe SLE activity (adjusted OR 4.07, 95% CI 1.11\u201314.82, <jats:italic>P<\/jats:italic> = 0.033). The administration of MP resulted in reduced average dosages of prednisone during the first year among patient with moderate (mean 6.6 vs 10.2 mg\/day, <jats:italic>P<\/jats:italic> = 0.017) and severe activity (mean 14 vs 28 mg\/day, <jats:italic>P<\/jats:italic> = 0.015). The odds of prolonged remission were increased by longer\u2010term use of hydroxychloroquine (HCQ) and decreased by higher initial doses of prednisone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study supports the use of MP to induce prolonged remission in patients with SLE, particularly in those with moderate and severe activity. The extended use of HCQ also contributes to achieve prolonged remission.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/acr25334-toc-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25334","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T05:20:00Z","timestamp":1711430400000},"page":"1132-1138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Methylprednisolone Pulses and Prolonged Remission in Systemic Lupus Erythematosus: A Propensity Score Analysis of the Longitudinal Lupus\u2010Cruces\u2010Bordeaux Inception Cohort"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7788-1043","authenticated-orcid":false,"given":"Guillermo","family":"Ruiz\u2010Irastorza","sequence":"first","affiliation":[{"name":"Biobizkaia Health Research Institute and University of The Basque Country\u2010UPV\/EHU  Bizkaia Basque Country Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8378-8638","authenticated-orcid":false,"given":"Diana","family":"Paredes\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Biobizkaia Health Research Institute  Bizkaia Basque Country Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Herrero\u2010Galvan","sequence":"additional","affiliation":[{"name":"University of The Basque Country\u2010UPV\/EHU  Bizkaia Basque Country Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9798-4514","authenticated-orcid":false,"given":"Victor","family":"Moreno\u2010Torres","sequence":"additional","affiliation":[{"name":"Hospital Universitario Cruces, Bizkaia, Basque Country, UNIR Health Sciences School and Hospital Universitario Puerta de Hierro Majadahonda  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9992-9148","authenticated-orcid":false,"given":"Halbert","family":"Hernandez\u2010Negrin","sequence":"additional","affiliation":[{"name":"Hospital Universitario Cruces, Bizkaia, Basque Country, Hospital Regional Universitario de M\u00e1laga and Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9628-4022","authenticated-orcid":false,"given":"Ioana","family":"Ruiz\u2010Arruza","sequence":"additional","affiliation":[{"name":"Biobizkaia Health Research Institute and University of The Basque Country\u2010UPV\/EHU  Bizkaia Basque Country Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Leonard","sequence":"additional","affiliation":[{"name":"Bordeaux Hospital University  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3029-8739","authenticated-orcid":false,"given":"Christophe","family":"Richez","sequence":"additional","affiliation":[{"name":"Bordeaux Hospital University  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4206-7399","authenticated-orcid":false,"given":"Estibaliz","family":"Lazaro","sequence":"additional","affiliation":[{"name":"Bordeaux Hospital University  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215089"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203320930099"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-222487"},{"issue":"1","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2021-000538","article-title":"2021 DORIS definition of remission in SLE: final recommendations from an international task force","volume":"8","author":"Vollenhoven RF","year":"2021","journal-title":"Lupus Sci 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