{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:22:29Z","timestamp":1788276149188,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930071"],"award-info":[{"award-number":["81930071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072502"],"award-info":[{"award-number":["82072502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20352"],"award-info":[{"award-number":["U21A20352"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ20100"],"award-info":[{"award-number":["2022JJ20100"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30893"],"award-info":[{"award-number":["2023JJ30893"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for the Central Universities of Central South University","doi-asserted-by":"publisher","award":["2024ZZTS0032"],"award-info":[{"award-number":["2024ZZTS0032"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Although hand synovitis is prevalent in the older population, the etiology remains unclear. Hyperuricemia, a modifiable metabolic disorder, may serve as an underlying mechanism of hand synovitis, but little is known about their relationship. We assessed the association between hyperuricemia and hand synovitis in a large population\u2010based sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional study in Longshan County, Hunan Province, China. Hyperuricemia was defined as a serum urate level &gt;420 \u03bcmol\/L in men and &gt;360 \u03bcmol\/L in women. Ultrasound examinations were performed on both hands of 4,080 participants, and both gray\u2010scale synovitis and the Power Doppler signal (PDS) were assessed using semiquantitative scores (grades 0\u20133). We evaluated the association of hyperuricemia with hand gray\u2010scale synovitis (grade \u22652) and PDS (grade \u22651), respectively, adjusting for age, sex, and body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All required assessments for analysis were available for 3,286 participants. The prevalence of hand gray\u2010scale synovitis was higher among participants with hyperuricemia (30.0%) than those with normouricemia (23.3%), with an adjusted odds ratio (aOR) of 1.28 (95% confidence interval [CI] 1.00\u20131.62). Participants with hyperuricemia also had a higher prevalence of PDS (aOR 2.36; 95% CI 1.15\u20134.81). Furthermore, hyperuricemia positively associated, both at the hand and joint levels, with the presence of gray\u2010scale synovitis (aOR 1.27; 95% CI 1.00\u20131.60 and adjusted prevalence ratio [aPR] 1.26; 95% CI 1.10\u20131.44, respectively) and PDS (aOR 2.35; 95% CI 1.15\u20134.79 and aPR 2.34; 95% CI 1.28\u20134.30, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This population\u2010based study provides more evidence for a positive association between hyperuricemia and prevalent hand synovitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25342","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:14:45Z","timestamp":1712189685000},"page":"1187-1194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Hyperuricemia and Ultrasound\u2010Detected Hand Synovitis"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5604-7989","authenticated-orcid":false,"given":"Ting","family":"Jiang","sequence":"first","affiliation":[{"name":"Xiangya Hospital, Central South University, Changsha, China, the University of Nottingham, and Pain Centre Versus Arthritis UK  Nottingtham United\u00a0Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7703-7042","authenticated-orcid":false,"given":"Qianlin","family":"Weng","sequence":"additional","affiliation":[{"name":"Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7638-0888","authenticated-orcid":false,"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School  Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1142-1460","authenticated-orcid":false,"given":"Weiya","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Nottingham and Pain Centre Versus Arthritis UK  Nottingham United\u00a0Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5763-8326","authenticated-orcid":false,"given":"Michael","family":"Doherty","sequence":"additional","affiliation":[{"name":"University of Nottingham and Pain Centre Versus Arthritis UK  Nottingham United\u00a0Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliya","family":"Sarmanova","sequence":"additional","affiliation":[{"name":"University of Bristol  Bristol United\u00a0Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zidan","family":"Yang","sequence":"additional","affiliation":[{"name":"Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0738-4812","authenticated-orcid":false,"given":"Tuo","family":"Yang","sequence":"additional","affiliation":[{"name":"Xiangya Hospital, Central South University, Changsha, China, the University of Nottingham, and Pain Centre Versus Arthritis UK  Nottingtham United\u00a0Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiatian","family":"Li","sequence":"additional","affiliation":[{"name":"Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[{"name":"Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Xiangya Hospital, Central South University  Changsha 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