{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:30:56Z","timestamp":1787974256917,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Long\u2010term gout management is based on reducing serum urate by using urate\u2010lowering therapy (ULT). A lifelong treat\u2010to\u2010target approach is advocated, although a ULT (taper to) stop attempt can be considered (treat\u2010to\u2010avoid symptoms approach) during remission. Exploring the beliefs of patients with gout on long\u2010term ULT strategies during remission is important for optimizing gout management. We aimed to identify factors that influence the decision for continuation or discontinuation of ULT and to determine their relative importance according to patients with gout in remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A mixed\u2010methods design was used. First, semistructured interviews (substudy 1) were conducted to identify barriers and facilitators for the (dis)continuation of ULT using inductive thematic analysis. Afterwards, these barriers\/facilitators were summarized into neutrally phrased items and used in a maximum difference scaling study (substudy 2) to determine their relative importance using the rescaled probability score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Substudies 1 and 2 included 18 and 156 patients, respectively. Substudy 1 yielded 22 items within 10 overarching themes. Substudy 2 revealed that the perceived risk of joint damage and gout flares and that ULT use gives some assurance were the most important items. The costs, ease of receiving ULT, and its practical use were the least important items.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results can aid shared decision\u2010making and provide input for what is important to discuss with patients with gout in remission when they consider ULT discontinuation. The emphasis should be on the risk of having gout flares and joint damage, not so much on facilitating how easily medication is received.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25392","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T23:29:40Z","timestamp":1719271780000},"page":"1574-1583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Perspective of Dutch Patients with Gout on Continuation or Discontinuation of Urate\u2010Lowering Therapy During Remission: A Mixed\u2010Methods Study"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7991-6112","authenticated-orcid":false,"given":"Iris Rose","family":"Peeters","sequence":"first","affiliation":[{"name":"Sint Maartenskliniek, Ubbergen, the Netherlands and Radboud University  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8627-6670","authenticated-orcid":false,"given":"Frouwke","family":"Veenstra","sequence":"additional","affiliation":[{"name":"Sint Maartenskliniek, Ubbergen, the Netherlands and Radboud University  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie A. 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