{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:16:07Z","timestamp":1790226967538,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Systemic sclerosis (SSc) is a rare, chronic autoimmune disorder associated with disability, diminished physical function, fatigue, pain, and mental health concerns. We assessed minimal detectable changes (MDCs) of the Health Assessment Questionnaire\u2013Disability Index (HAQ\u2010DI), Patient\u2010Reported Outcomes Measurement Information System\u201029 Profile version 2.0 (PROMIS\u201029v2.0) domains, and Patient Health Questionnaire (PHQ)\u20108 in people with SSc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Scleroderma Patient\u2010Centered Intervention Network Cohort participants completed the HAQ\u2010DI, PROMIS\u201029v2.0 domains, and PHQ\u20108 at baseline assessments from April 2014 until August 2023. We estimated MDC95 (smallest change that can be detected with 95% certainty) and MDC90 (smallest change that can be detected with 90% certainty) with 95% confidence intervals (CIs) generated via the percentile bootstrapping method resampling 1,000 times. We compared MDC estimates by age, sex, and SSc subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2,571 participants were included. Most were female (n = 2,241; 87%), and 38% (n = 976) had diffuse SSc. Mean (\u00b1SD) age was 54.9 (\u00b112.7) years and duration since onset of first non\u2010Raynaud phenomenon symptom was 10.8 (\u00b18.7) years. MDC95 estimate was 0.41 points (95% CI 0.40\u20130.42) for the HAQ\u2010DI, between 4.88 points (95% CI 4.72\u20135.05) and 9.02 points (95% CI 8.80\u20139.23) for the seven PROMIS\u201029v2.0 domains, and 5.16 points (95% CI 5.06\u20135.26) for the PHQ\u20108. MDC95 estimates were not materially different across subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MDC95 and MDC90 estimates were precise and similar across age, sex, and SSc subtype groups. HAQ\u2010DI MDC95 and MDC90 were substantially larger than previous estimates of HAQ\u2010DI minimal important difference from several small studies. Minimally important differences of all measures should be evaluated in large studies using anchor\u2010based methods.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25397","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T01:49:49Z","timestamp":1719452989000},"page":"1549-1557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Minimal Detectable Changes of the Health Assessment Questionnaire\u2013Disability Index, Patient\u2010Reported Outcomes Measurement Information System\u201029 Profile Version 2.0 Domains, and Patient Health Questionnaire\u20108 in People With Systemic Sclerosis: A Scleroderma Patient\u2010Centered Intervention Network Cohort Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9734-4138","authenticated-orcid":false,"given":"Afra","family":"Alkan","sequence":"first","affiliation":[{"name":"Lady Davis 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