{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:51:14Z","timestamp":1759452674035,"version":"build-2065373602"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P30AR076316","P30 AR070549"],"award-info":[{"award-number":["5P30AR076316","P30 AR070549"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We examine levels of candidate blood\u2010based biomarkers (CBBs) in patients with juvenile idiopathic arthritis (JIA) treated with tofacitinib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with JIA who participated in clinical trial NCT02592434 received tofacitinib from baseline to week 18. Serial serum samples were assayed for CBBs (S100A8\/9, S100A12, interleukin\u201018 [IL\u201018], serum amyloid A, resistin, vascular endothelial growth factor, angiopoietin\u20101, angiopoietin\u20102, matrix metalloproteinase 8 [MMP8], MMP2, tissue inhibitor of metalloproteinases 1, leptin, chemokine [C\u2010X\u2010C motif] ligand 9, soluble IL\u20102 receptor, intercellular adhesion molecule 1, soluble tumor necrosis factor receptor, IL\u20106, IL\u201023, monocyte chemotactic protein 1, chemokine [C\u2010C motif] ligand 18 [CCL18], and CCL20). Association of CBBs with JIA response to treatment from baseline to week 18 were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study included 166 patients with polyarticular\u2010course JIA. Paired serum samples from 143 patients were available at both baseline and week 18. Thirty\u2010five percent (50 of 143) of patients had a JIA\u2010American College of Rheumatology 90 (JIA\u2010ACR90) level improvement, whereas 90, 121, and 137 (63%, 85%, and 96%) achieved JIA\u2010ACR70, 50, and 30 improvement at week 18. Despite small numerical differences by JIA category, there were no baseline CBB values that independently predicted a decrease in Juvenile Arthritis Disease Activity Score (JADAS\u201027) or JIA\u2010ACR90 response by week 18. Decrease in resistin level (baseline to week 18) was significantly associated with week 18 improvement in JADAS\u201027 and JIA\u2010ACR90 response after adjusting for age, sex, JIA disease duration, and baseline resistin (r<jats:sup>2<\/jats:sup> 0.79, SE 0.070, <jats:italic>P<\/jats:italic> &lt; 0.01, and odds ratio [95% confidence interval] 1.134 [1.018\u20131.264]). HLA\u2010B27 positivity was significantly associated with not achieving a JIA\u2010ACR90 response at week 18 (<jats:italic>P<\/jats:italic> = 0.0097).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among the CBBs included, only resistin was significantly associated with treatment response, and no CBB was identified that forecasts JIA improvement after initiation of tofacitinib. The association of HLA\u2010B27 positivity with lower response to tofacitinib in JIA is intriguing and merits further study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25417","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T02:54:26Z","timestamp":1723517666000},"page":"1723-1732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biomarker Changes in Response to Tofacitinib Treatment in Patients With Polyarticular\u2010Course Juvenile Idiopathic Arthritis"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2126-1587","authenticated-orcid":false,"given":"Ekemini A.","family":"Ogbu","sequence":"first","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Ohio, and Johns Hopkins University  Baltimore 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