{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:47:28Z","timestamp":1789156048068,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T00:00:00Z","timestamp":1735430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The National Institute of Health and Care Excellence (NICE) criteria for osteoarthritis (OA) obviate the need for physical examination or imaging, and their use may improve timely diagnosis of OA. However, they have not been validated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Within a larger study of individuals with type 2 diabetes, participants with and without self\u2010reported knee pain underwent assessment of the NICE criteria for knee OA by questionnaire (index test) and clinical evaluation for established or possible knee OA by a rheumatologist (reference standard). We calculated the sensitivity, specificity, likelihood ratio positive (LR+), and likelihood ratio negative (LR\u2212) of the NICE criteria and modified NICE criteria without the stiffness criterion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our study included 96 participants: the mean \u00b1 SD age was 65.4 \u00b1 8.3 years and 52% were women. Individuals who fulfilled the NICE criteria for knee OA (55.2%) included a spectrum of pain severity on an 11\u2010point pain numeric rating scale with a median score of 5 (range 1\u20139). Rheumatologist assessment identified 56 participants (58.3%) with symptomatic knee OA. The sensitivity, specificity, LR+, and LR\u2212 of the NICE criteria for symptomatic knee OA were 0.84 (95% confidence interval [CI] 0.74\u20130.94), 0.85 (95% CI 0.74\u20130.96), 5.6, and 0.19, respectively. For the modified NICE criteria, these were 0.89 (95% CI 0.82\u20130.97), 0.85 (95% CI 0.74\u20130.96), 5.93, and 0.13.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The NICE criteria have high sensitivity and specificity for detecting symptomatic knee OA in a population with type 2 diabetes. We found that a modified version, omitting the stiffness criterion, performed similarly. These criteria should be validated in other settings and populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.25464","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T22:12:08Z","timestamp":1731622328000},"page":"623-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["National Institute of Health and Care Excellence Clinical Criteria for the Diagnosis of Knee Osteoarthritis: A Prospective Diagnostic Accuracy Study in Individuals With Type 2 Diabetes"],"prefix":"10.1002","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4721-5696","authenticated-orcid":false,"given":"Lauren K.","family":"King","sequence":"first","affiliation":[{"name":"University of Toronto and St. Michael's Hospital, Unity Health  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Stanaitis","sequence":"additional","affiliation":[{"name":"Women's College Hospital  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Hung","sequence":"additional","affiliation":[{"name":"Women's College Hospital  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Koppikar","sequence":"additional","affiliation":[{"name":"University of Toronto and Women's College Hospital  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther J.","family":"Waugh","sequence":"additional","affiliation":[{"name":"University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Lipscombe","sequence":"additional","affiliation":[{"name":"University of Toronto and Women's College Hospital  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6358-1197","authenticated-orcid":false,"given":"Gillian A.","family":"Hawker","sequence":"additional","affiliation":[{"name":"University of Toronto and Women's College Hospital  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216515"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24861"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocarto.2020.100115"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-018-2196-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30417-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22171"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210815"},{"key":"e_1_2_7_9_1","unstructured":"National Institute for Health and Clinical Excellence.Osteoarthritis in over 16s: diagnosis and management. 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