{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:04:44Z","timestamp":1791986684249,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T00:00:00Z","timestamp":1734825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Osteoporosis, a known complication of rheumatoid arthritis (RA), increases the risk of hip fracture, which is associated with high morbidity and mortality. Fracture risk estimates in patients with RA treated with contemporary treatment strategies are lacking. The objectives were (1) estimate age\u2010specific and sex\u2010specific incidence rates and compare the risk of hip fractures in RA relative to age\u2010matched and sex\u2010matched general population controls, and (2) compare the risk of all\u2010cause mortality in RA and general population controls after hip fracture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A longitudinal study of a population\u2010based incident cohort of patients with RA diagnosed between 1997 and 2009, followed until 2014, with age\u2010matched and sex\u2010matched controls from the general population of British Columbia, using administrative health data. Hip fracture outcomes (International Classification of Diseases, Ninth Edition, Clinical Modification [ICD\u20109\u2010CM] codes 820.0 or 820.2; ICD\u201010\u2010Canada code S72.0 to S72.2) and mortality at predefined intervals after fracture (in hospital, 90 days, 1\u2010year, 5\u2010year) were identified. Hip fracture incidence rates for RA and controls, and incidence rate ratios (IRRs), were calculated. Cox proportional hazards models compared hip fracture and mortality risk in RA versus controls; logistic regression compared in\u2010hospital mortality risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 1,314 hip fractures over 360,521 person\u2010years were identified in 37,616 individuals with RA and 2,083 over 732,249 person\u2010years in 75,213 controls, yielding a 28% greater fracture risk in RA (IRR 1.28 [95% confidence interval 1.20\u20131.37]). Mean age at time of fracture was slightly younger for RA than controls (79.6 \u00b1 10.8 vs 81.6 \u00b1 9.3 years). Postfracture mortality risk at one\u2010year and five\u2010years did not differ between RA and general population controls. Results were similar in a sensitivity analysis including only individuals with RA who received disease\u2010modifying antirheumatic drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>People with RA had a greater risk of hip fractures, but no greater risk of mortality post fracture, than the general population. The relative risk of hip fractures observed was not as high as previously reported, likely reflecting better treatment of inflammation and management of osteoporosis and its risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25466","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T22:03:50Z","timestamp":1731621830000},"page":"604-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Incidence of and Risk of Mortality After Hip Fractures in Rheumatoid Arthritis Relative to the General Population"],"prefix":"10.1002","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3952-3234","authenticated-orcid":false,"given":"C. 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