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At least two diagnosis codes \u226530 days apart were used to identify CTS. Cumulative incidence of CTS adjusting for competing risk of death was assessed. Logistic regression and Cox proportional hazard models were used, adjusting for age, sex, calendar year, smoking, obesity, diabetes mellitus, and hypothyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 1,335 patients with RA and 1,331 individuals without RA. The overall prevalence of CTS before or on RA incidence or index was 179 patients with RA (13%) and 85 individuals without RA (6%), respectively (odds ratio [OR] 2.23; 95% confidence interval [CI] 1.69\u20132.94). Most previous incidences of CTS occurred \u22652 years before the index date (112 events in patients with RA and 75 events in individuals without RA, respectively). Following RA incidence or index, individuals with RA (vs those without RA) had ~80%\u2010higher risk of CTS (hazard ratio [HR] 1.78; 95% CI 1.38\u20132.30). The risk estimates of CTS in patients with seronegative (vs seropositive) RA were OR 1.33 (95% CI 0.96\u20131.84) before RA incidence and HR 1.37 (95% CI 0.99\u20131.88) after RA incidence. In RA, obesity (HR 1.42, 95% CI 1.02\u20131.99) and seronegative cyclic citrullinated peptide antibody status (HR 1.79, 95% CI 1.07\u20132.99), but not other risk factors, were associated with increased CTS risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found a more than two\u2010fold increase in risk of CTS in the years preceding RA and a 1.8\u2010fold increased risk of incident CTS following RA onset.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/acr25566-toc-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.25566","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T10:06:09Z","timestamp":1746439569000},"page":"1332-1339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Carpal Tunnel Syndrome as an Early Underrecognized Feature of Rheumatoid Arthritis: A Population\u2010Based Study of Carpal Tunnel Syndrome Occurrence Before and After Rheumatoid Arthritis Incidence"],"prefix":"10.1002","volume":"77","author":[{"given":"Roslin Jose","family":"George","sequence":"first","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Frechette","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester 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