{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:25:39Z","timestamp":1790421939054,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100003358","name":"Scleroderma Foundation-Tri-State","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003358","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Scleroderma renal crisis (SRC) is historically described to occur within the first five years of systemic sclerosis (SSc) diagnosis. However, it has been observed to occur beyond five years. In this analysis, we aim to describe the prevalence, clinical features, and outcomes of late\u2010onset SRC and compare them with early\u2010onset SRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study included patients diagnosed with SRC between 1995 and 2018 at three university\u2010affiliated hospitals. Late\u2010onset SRC was defined as SRC occurring five years after SSc diagnosis. After obtaining institutional review board approval, data including demographics, SRC onset, clinical characteristics, laboratory data, and outcomes were extracted. Continuous data were expressed as mean\/median and categorical data as frequencies\/percentages. Differences were analyzed via Pearson's chi\u2010square test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 223 patients with SRC were identified, with 169 (75.8%) classified as early onset and 54 (24.2%) as late onset. The late\u2010onset group had a mean SRC onset of 12.2 years after SSc diagnosis. Male predominance was observed in the late\u2010onset compared with the early\u2010onset group (59% vs 9%). Steroid exposure was more common in late vs early group (56% vs 29%). There was no evidence of difference in autoantibodies profile and outcomes between early\u2010 and late\u2010onset groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Late\u2010onset SRC was seen in up to 25% of patients with SRC, with a mean of 12 years after SSc diagnosis. Our findings reveal comparable clinical characteristics and outcomes between early\u2010 and late\u2010onset SRC, underlying the importance of recognizing SRC regardless of disease duration to optimize outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.25608","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T09:14:51Z","timestamp":1752484491000},"page":"208-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Late\u2010Onset Scleroderma Renal Crisis Does Occur\u2014A Multicenter Study"],"prefix":"10.1002","volume":"78","author":[{"given":"Swati","family":"Mehta","sequence":"first","affiliation":[{"name":"Albany Medical Center  Albany New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7113-441X","authenticated-orcid":false,"given":"Sumbal","family":"Wajid","sequence":"additional","affiliation":[{"name":"Albany Medical Center  Albany New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isam","family":"Albaba","sequence":"additional","affiliation":[{"name":"Temple University  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Steen","sequence":"additional","affiliation":[{"name":"MedStar Georgetown University Hospital  Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn T.","family":"Domsic\u2010Degazio","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Luta","sequence":"additional","affiliation":[{"name":"MedStar Georgetown University Hospital  Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Feustel","sequence":"additional","affiliation":[{"name":"Albany Medical College  Albany New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loay","family":"Salman","sequence":"additional","affiliation":[{"name":"Albany Medical Center  Albany New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Albany Medical Center  Albany New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31139"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2021.104063"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(03)00016-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(21)00892-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.12.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.09.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40809"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2005.03.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320911"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90986-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2014.02.031"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e3182583ba1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-023-03416-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.01.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcm052"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1422.027"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2024-226430"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker271"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200011)43:11<2437::AID-ANR10>3.0.CO;2-U"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-022-08945-x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-8-200010170-00010"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38219"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.171186"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2018.08.010"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27549"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2022.01.020"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.25608","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.25608","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.25608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:34:11Z","timestamp":1772969651000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.25608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/acr.25608"],"URL":"https:\/\/doi.org\/10.1002\/acr.25608","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]},"assertion":[{"value":"2025-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}