{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:20:13Z","timestamp":1790965213160,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of baricitinib in pediatric patients with active juvenile idiopathic arthritis\u2013associated uveitis (JIA\u2010U) or chronic anterior antinuclear antibody\u2013positive uveitis, who had an inadequate response to methotrexate (MTX) or biologic disease\u2010modifying antirheumatic drugs (bDMARDs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>JUVE\u2010BRIGHT was an open\u2010label, active\u2010controlled phase\u20103 multicenter trial that used a novel design, including 1:1 randomization to an active reference arm. The primary efficacy endpoint was the proportion of responders at week 24 (W24), defined according to the Standardization of Uveitis Nomenclature (SUN) criteria as a two\u2010step decrease in the level of inflammation (anterior chamber cells) or decrease to zero through W24 in the most severely affected eye at baseline. Study success was based on a prespecified Bayesian success rule: the study was deemed successful if there was &gt;80% posterior probability that the baricitinib SUN criteria response rate at W24 was at least 57%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study enrolled 30 pediatric patients. The study primary endpoint was not met. In the baricitinib group, 36.8% of MTX\u2013inadequate responder (MTX\u2010IR) and bDMARD\u2010IR patients and 20% of MTX\u2010IR patients achieved a two\u2010step decrease in SUN criteria at W24. Eight patients (33.3%) achieved a response at W24, resulting in 1.03% posterior probability of a response rate of &gt;57%. Safety data were consistent with the established safety profile in other baricitinib indications in pediatric and adult patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although the primary endpoint was not met, the data provide important information on baricitinib for the treatment of children with JIA\u2010U refractory to both MTX and bDMARDs. Baricitinib safety profile in this study was consistent with previous studies in children and adults with other diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.25644","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T03:59:36Z","timestamp":1757908776000},"page":"431-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness and Safety of Baricitinib for Juvenile Idiopathic Arthritis\u2013Associated Uveitis or Chronic Anterior Antinuclear Antibody\u2013Positive Uveitis"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8663-2401","authenticated-orcid":false,"given":"Athimalaipet V.","family":"Ramanan","sequence":"first","affiliation":[{"name":"Bristol Royal Hospital for Children and Translational Health Sciences  Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Guly","sequence":"additional","affiliation":[{"name":"Bristol Eye Hospital, University Hospitals Bristol and Weston NHS Foundation Trust  Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Simonini","sequence":"additional","affiliation":[{"name":"ERN ReConnet Center, Meyer Children's Hospital IRCCS and University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart Y.","family":"Keller","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Sen","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Holzkaemper","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Quartier","sequence":"additional","affiliation":[{"name":"RAISE Reference Centre for Rare Diseases, Necker\u2010Enfants Malades Hospital, Assistance Publique\u2010Hopitaux de Paris and Universit\u00e9 Paris\u2010cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130302"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/461078"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-016-0088-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-0087-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2013.791701"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2019.108322"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-021-05651-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213131"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24963"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000723"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614160"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212089"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa595"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-315060"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-016-3497-5"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.171006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(20)30008-4"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2023.2207823"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04875-w"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2022.2069128"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2019.1605453"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-eular.1983"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1608345"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00921-2"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400703"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6225"}],"container-title":["Arthritis Care &amp; 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