{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:42:48Z","timestamp":1788903768984,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019211","name":"AbbVie Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013739","name":"Pfizer Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013018","name":"Hospital for Special Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014369","name":"Organon BioSciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014369","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to understand the association of nonarticular pain (NAP), regional and widespread, with patient\u2010reported outcomes in early rheumatoid arthritis (RA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This real\u2010world, multicenter study observed participants with newly diagnosed active early RA (symptoms &lt;1 year; Clinical Disease Activity Index [CDAI] score &gt;2.8) over the first year. Participants were examined by rheumatologists and synchronously completed body pain diagrams and Patient\u2010Reported Outcomes Measurement Information System 29 (PROMIS\u201029) measures at regular intervals. Participants were classified as follows: (1) no NAP, (2) regional NAP, or (3) widespread NAP. Associations between repeated measures of NAP\u2009and PROMIS\u201029 over the first year were estimated in separate mixed models, adjusting for sociodemographic and RA characteristics and time\u2010varying CDAI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>These 472 participants with early RA were mostly women (66%), had a mean age of 57 (SD 14) years, and had active disease (mean CDAI 27.0 [SD 14.1]). Over one\u2010half (n = 246, 52%) reported NAP at baseline; of these, 72% (176 of 246) had regional NAP, and 28% (70 of 246) had widespread NAP. Adjusted mean change in PROMIS\u201029 domains were significantly worse in patients with regional versus no NAP: physical function \u20101.4 (95% confidence interval [CI] \u20102.1 to \u20100.7), pain interference 2.7 (95% CI 1.9\u20133.5), sleep disturbance 1.2 (95% CI 0.4\u20132.0), fatigue 2.1 (95% CI 1.2\u20133.1), anxiety 1.5 (95% CI 0.7\u20132.4), depression 1.4 (95% CI 0.5\u20132.2), and social participation \u20102.4 (95% CI \u20103.3 to \u20101.5). Associations between widespread and no NAP were larger for pain interference (5.0 [95% CI 3.7\u20136.4]), fatigue (3.2 [95% CI 1.7\u20134.8]), and social participation (\u20105.6 [95% CI \u20107.2 to \u20104.0]). Mean physical function, pain interference, and social participation scores were well outside the normal range.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NAP interferes with key aspects of well\u2010being in early RA. Individuals with NAP experience greater pain interference and impairments in physical and social function, supporting a need for earlier identification of and interventions targeting NAP.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/acr25656-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.25656","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:59:12Z","timestamp":1758268752000},"page":"38-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Thinking Outside the Joints: The Impact of Nonarticular Pain on Patient\u2010Reported Outcomes in a Prospective Longitudinal Real\u2010World Early Rheumatoid Arthritis Cohort"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9723-5791","authenticated-orcid":false,"given":"Charis F.","family":"Meng","sequence":"first","affiliation":[{"name":"Hospital for Special Surgery, Weill Cornell Medical College  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010France","family":"Valois","sequence":"additional","affiliation":[{"name":"McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2105-3393","authenticated-orcid":false,"given":"Yvonne C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia D.","family":"Caci","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2481-5821","authenticated-orcid":false,"given":"Gilles","family":"Boire","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7709-3741","authenticated-orcid":false,"given":"Glen","family":"Hazlewood","sequence":"additional","affiliation":[{"name":"University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7850-2658","authenticated-orcid":false,"given":"Hugues","family":"Allard\u2010Chamard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5547-3268","authenticated-orcid":false,"given":"Carol","family":"Hitchon","sequence":"additional","affiliation":[{"name":"University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindee","family":"Kuriya","sequence":"additional","affiliation":[{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carter","family":"Thorne","sequence":"additional","affiliation":[{"name":"Southlake Regional Health Centre, Centre of Arthritis Excellence, The Arthritis Program Research 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