{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:31:32Z","timestamp":1792063892128,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08AR081402"],"award-info":[{"award-number":["K08AR081402"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR081280"],"award-info":[{"award-number":["R01AR081280"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R33AR078078"],"award-info":[{"award-number":["R33AR078078"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R61AR078078"],"award-info":[{"award-number":["R61AR078078"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large\u2010scale comparison of US\u2010based assessment with histologic markers of skin fibrosis has not been reported. We evaluated US\u2010based skin assessments for their face validity (differentiation between involved SSc and healthy control [HC] skin), construct validity (comparison to modified Rodnan skin score [mRSS]), and criterion validity (comparison to histologic and gene expression fibrosis markers).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty HCs and 52 patients with SSc underwent clinical and US assessment followed by a forearm skin biopsy. Predefined areas were assessed on the finger, hand, and forearm bilaterally. mRSS, US, histologic and molecular (reverse transcription quantitative polymerase chain reaction) evaluations were performed by blinded, independent assessors. Dermal thickness, echogenicity, and elastography were assessed using a high\u2010frequency GE LOGIQ P9 US machine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Except in the hand area, the US variables could not differentiate between HC and clinically affected SSc skin (face validity). There was only a weak to moderate correlation between US\u2010based measurements and mRSS in the hand and finger areas (construct validity). US\u2010based thickness showed moderate correlation with histologic thickness (\u03c1 = 0.43;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002) but no statistically significant correlations with other histologic or gene expression markers of fibrosis in patients with SSc (criterion validity).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High\u2010frequency US assessment of SSc skin does not show consistent and strong face, construct, or criterion validity. The role of this assessment tool remains limited, underscoring the need for further development of a quantitative and accurate tool for assessing SSc skin fibrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.25658","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T07:24:55Z","timestamp":1760599495000},"page":"582-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of Skin in Patients With Systemic Sclerosis Using High\u2010Frequency Ultrasound and Shear Wave Elastography: A Comparative Study With Histology, Molecular, and Clinical Parameters"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2499-4714","authenticated-orcid":false,"given":"Ruhani","family":"Desai","sequence":"first","affiliation":[{"name":"Macon &amp; Joan Brock Virginia Health Sciences at Old Dominion University Eastern Virginia Medical Schoo  Norfolk Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filemon","family":"Tan","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston John P. and Katherine G. McGovern Medical School  Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghua","family":"Wu","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston John P. and Katherine G. McGovern Medical School  Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery L.","family":"Browning","sequence":"additional","affiliation":[{"name":"Boston University  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Theodore","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston John P. and Katherine G. McGovern Medical School  Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston John P. and Katherine G. McGovern Medical School  Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6689-4655","authenticated-orcid":false,"given":"Brian","family":"Skaug","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston John P. and Katherine G. McGovern Medical School  Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3222-8613","authenticated-orcid":false,"given":"Harshdeep Singh","family":"Chawla","sequence":"additional","affiliation":[{"name":"University of Houston  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manmohan","family":"Singh","sequence":"additional","affiliation":[{"name":"University of Houston  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salavat","family":"Aglyamov","sequence":"additional","affiliation":[{"name":"University of Houston  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill V.","family":"Larin","sequence":"additional","affiliation":[{"name":"University of Houston  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5070-2535","authenticated-orcid":false,"given":"Maureen","family":"Mayes","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston John P. and Katherine G. McGovern Medical School  Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-9978","authenticated-orcid":false,"given":"Shervin","family":"Assassi","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston John P. and Katherine G. 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