{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:18:06Z","timestamp":1778167086548,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K24AR078950"],"award-info":[{"award-number":["K24AR078950"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2026,5]]},"abstract":"\n Objective<\/jats:title>\n Maturational signal in the sacroiliac joint (SIJ) of skeletally immature youth is often misinterpreted as inflammation. Diagnostic tools that improve specificity are greatly needed. Apparent diffusion coefficient (ADC) values from diffusion\u2010weighted imaging (DWI), when used with standard imaging, may enhance diagnostic accuracy. We aimed to define normative pediatric ADC values and establish thresholds to distinguish normal from inflammatory SIJ signals.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n ADC values were measured using circular regions of interest (ROIs) on the anterior, central, and posterior slices of the cartilaginous SIJs (36 total ROIs). Mean ADCs were analyzed by age group, bone (iliac or sacral), and joint height (superior, mid, inferior), accounting for within\u2010patient clustering. In sacroiliitis cases, ROIs were placed on DWI at sites of increased signal on fluid\u2010sensitive sequences. Thresholds differentiating normal and inflammatory signals were derived by age, bone, and joint height (ilium only) and assessed by area under the receiver operating characteristic (AUROC) and specificity.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The reference group included 86 youth. Inferior ilium ADC values were higher than mid and superior regions in all immature age groups (all\n P<\/jats:italic>\n < 0.0001) and decreased with age (\n P<\/jats:italic>\n = 0.0001). Sacral ADCs also declined with age (\n P<\/jats:italic>\n = 0.0001). No age trend was observed in the superior or mid ilium (\n P<\/jats:italic>\n = 0.14). ADC thresholds distinguished normal from inflammatory signals with AUROC \u22650.90 in most iliac regions, except the peripubertal inferior ilium (AUROC 0.78). Sacral thresholds performed acceptably (AUROC \u2265 0.77), though they were lower in the prepubertal group (AUROC 0.68).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Age\u2010 and bone\u2010specific ADC reference values were established and effectively differentiated normal from inflammatory SIJ signals.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acr.25661","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T02:55:37Z","timestamp":1759373737000},"page":"630-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diffusion\u2010Weighted Imaging for the Evaluation of the Sacroiliac Joint in Pediatric Patients"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1347-7097","authenticated-orcid":false,"given":"Michael L.","family":"Francavilla","sequence":"first","affiliation":[{"name":"Whiddon College of Medicine, University of South Alabama Mobile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1305-4871","authenticated-orcid":false,"given":"Timothy G.","family":"Brandon","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Khrichenko","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Xiao","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy A.","family":"Chauvin","sequence":"additional","affiliation":[{"name":"The Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asef","family":"Khwaja","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-0443","authenticated-orcid":false,"given":"Pamela F.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia Philadelphia Pennsylvania"},{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.054098"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050446"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22181"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100090"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24206"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-023-05602-z"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22665"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20150775"},{"issue":"2","key":"e_1_2_6_11_1","first-page":"131","article-title":"Efficacy of diffusion weighted imaging in sacroiliac joint MRI in children","volume":"10","author":"Tasar S","year":"2023","journal-title":"North Clin Istanb"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2021.07.003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2021.07.009"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3865"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-007-0407-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2013.08.032"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39434"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39257"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25209"},{"issue":"3","key":"e_1_2_6_20_1","first-page":"399","article-title":"Diffusion\u2010weighted imaging is a sensitive biomarker of response to biologic therapy in enthesitis\u2010related arthritis","volume":"56","author":"J P Bray T","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.17.18636"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.18.20708"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25565"},{"issue":"2","key":"e_1_2_6_24_1","first-page":"390","article-title":"et al; International League of Associations for Rheumatology. 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