{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:35:22Z","timestamp":1791380122176,"version":"4.3.3"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24 AR070892"],"award-info":[{"award-number":["K24 AR070892"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24 AR080840"],"award-info":[{"award-number":["K24 AR080840"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AR070254"],"award-info":[{"award-number":["P30 AR070254"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AR072571"],"award-info":[{"award-number":["P30 AR072571"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AR072579"],"award-info":[{"award-number":["P30 AR072579"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR064850"],"award-info":[{"award-number":["R01 AR064850"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32AR085530"],"award-info":[{"award-number":["T32AR085530"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigates the association between discordance in commonly collected clinical indicators of rheumatoid arthritis (RA) disease activity and abnormalities in quantitative sensory testing (QST) observed in individuals with nociplastic pain. The goal is to identify low\u2010burden methods of assessing nociplastic pain in rheumatology practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from 225 patients with active RA were included for cross\u2010sectional analyses. Measures of discordance in disease activity were as follows: (1) tender\u2013swollen joint count difference (TSJD), (2) proportion of subjective components to the total Disease Activity Score in 28 joints (DAS28\u2010P), and (3) patient global assessment of disease activity minus evaluator global assessment of Disease Activity (PtGA \u2212 EGA). QST measures were pressure pain thresholds (PPTs) at the trapezius, temporal summation (TS), and conditioned pain modulation. We evaluated associations between measures of discordance and QST using unadjusted and multivariable linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean TSJD was 5.4 (SD \u00b18.2), and the mean DAS28\u2010P was 49.7% (SD \u00b113.3%). The mean PtGA \u2212 EGA was 0.7 (SD \u00b12.2). Higher TSJD was associated with lower trapezius PPT (\u03b2 = \u22120.05; 95% confidence interval [CI] \u22120.08 to \u22120.02) and higher TS (\u03b2 = 0.29; 95% CI 0.05 to 0.53). Higher DAS28\u2010P was associated with a lower trapezius PPT (\u03b2 = \u22120.05; 95% CI \u22120.07 to \u22120.04) and higher TS (\u03b2 = 0.21; 95% CI 0.06 to 0.35). PtGA \u2212 EGA was not associated with any QST measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Two of our proposed measures of discordance (higher TSJD and DAS28\u2010P) were modestly associated with worse QST measures of nociplastic pain (lower trapezius PPT and higher TS), suggesting that discordance between patient\u2010reported and physician\u2010assessed measures of disease activity may reflect an element of nociplastic pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.25668","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T07:26:56Z","timestamp":1760599616000},"page":"47-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association Between Discordance of Disease Activity Indices and Quantitative Sensory Testing Measures of Nociplastic Pain in Patients With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7453-4085","authenticated-orcid":false,"given":"Clarice P.","family":"Lin","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0046-5452","authenticated-orcid":false,"given":"Burcu","family":"Aydemir","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8881-9664","authenticated-orcid":false,"given":"Jing","family":"Song","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutfiyya N.","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-1711","authenticated-orcid":false,"given":"Tuhina","family":"Neogi","sequence":"additional","affiliation":[{"name":"Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Marder","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifton O.","family":"Bingham","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5413-9345","authenticated-orcid":false,"given":"Marcy 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