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We explored associations between clinical characteristics and cognitive impairment in an RA cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were from a longitudinal RA cohort at Veterans Affairs Puget Sound Health Care System. Cognition was evaluated using the Saint Louis University Mental Status (SLUMS) examination. Demographics and health factors, objectively measured physical function, participant\u2010reported symptoms, RA disease characteristics, and comorbidities were evaluated. Univariable linear regressions explored the association between clinical factors and SLUMS scores. Those with\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.1 in the univariable models were evaluated in separate multivariable linear regressions controlling for age, sex, and years of education.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 145 participants with RA were included, with a mean age of 64.5 (SD 11.6) years, and were predominantly male (74%). Using SLUMS, 42 participants (29%) had normal cognition, 83 (57%) had mild cognitive impairment, and 20 (14%) had dementia. Physical performance (a\u03b2: 0.35, confidence interval [CI] 0.11 to 0.59), self\u2010reported exhaustion (a\u03b2: \u22122.22, CI \u22123.44 to \u22120.99), pain (a\u03b2: \u22120.25, CI \u22120.50 to \u22120.00), disability (a\u03b2: \u22121.79, CI \u22123.16 to \u22120.42), and trouble falling asleep (a\u03b2: \u22122.57, CI \u22124.00 to \u22121.14) were all independently associated with a lower SLUMS score (all\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cognitive impairment was prevalent in our cohort of veterans with RA and was associated with several modifiable clinical factors. Future longitudinal studies are needed to determine the directionality of these associations and evaluate interventions for modifiable risk factors that may mitigate cognitive dysfunction.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/acr25676-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.25676","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:27:42Z","timestamp":1761658062000},"page":"591-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Factors Associated With Cognitive Impairment in Rheumatoid Arthritis"],"prefix":"10.1002","volume":"78","author":[{"given":"Raquelle","family":"Dawood","sequence":"first","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington"},{"name":"Pacific Northwest University of Health Sciences  Yakima Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1964-5318","authenticated-orcid":false,"given":"Hannah F.","family":"Brubeck","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kylie E.","family":"Riggles","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-6828","authenticated-orcid":false,"given":"Sebastian E.","family":"Sattui","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2006-1436","authenticated-orcid":false,"given":"Elena","family":"Myasoedova","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4750-0777","authenticated-orcid":false,"given":"Una E.","family":"Makris","sequence":"additional","affiliation":[{"name":"VA North Texas Health Care System  Dallas"},{"name":"University of Texas Southwestern School of Medicine  Dallas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores M.","family":"Shoback","sequence":"additional","affiliation":[{"name":"San Francisco VA Medical Center  San Francisco California"},{"name":"University of California San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M.","family":"Garcia","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington"},{"name":"University of Washington School of Medicine  Seattle"},{"name":"VA Puget Sound GRECC  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariela R.","family":"Orkaby","sequence":"additional","affiliation":[{"name":"VA New England GRECC  Boston Massachusetts"},{"name":"VA Boston Healthcare System  Boston Massachusetts"},{"name":"Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua F.","family":"Baker","sequence":"additional","affiliation":[{"name":"Corporal Michael J. 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