{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:04:49Z","timestamp":1779703489324,"version":"3.53.1"},"reference-count":82,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["ZIAAR041204"],"award-info":[{"award-number":["ZIAAR041204"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Relapsing polychondritis (RP) is a rare disease defined by recurrent cartilaginous inflammation. Anti\u2013collagen II (Col2) antibodies have been proposed as a diagnostic biomarker for RP, but their performance characteristics are not well defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In an observational cohort, anti\u2010Col2 antibody levels were measured in patients with RP compared to other inflammatory diseases that mimic RP. In parallel, a systematic review and meta\u2010analysis was performed to assess anti\u2010Col2 antibody prevalence across a broad spectrum of diseases. Individual study risk ratios (RRs) and pooled disease category RRs, study bias, and interstudy heterogeneity were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the observational cohort, anti\u2010Col2 antibody prevalence did not differ between RP and comparators. The performance characteristics of anti\u2010Col2 to diagnose RP were poor (sensitivity\u00a0=\u00a018%; specificity\u00a0=\u00a072%). Anti\u2010Col2 antibody titers did not correlate with disease activity in RP (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.08,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.44). In the systematic review, 71 of 2,443 reviewed articles were included. Anti\u2010Col2 antibodies were not associated with RP across five pooled studies (RR:\u00a02.09; 95% confidence interval [CI]: 0.05\u201381.80;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.69). Anti\u2010Col2 antibodies were significantly associated with a composite group of inflammatory diseases with cartilaginous involvement (RR: 2.99; 95% CI: 1.29\u20136.91;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01). Studies using healthy controls reported increased effect sizes compared to studies that used disease controls (\u03b2\u2010estimate\u00a0=\u00a01.14,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u00a0=\u00a017.08%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anti\u2010Col2 antibodies are neither sensitive nor specific for RP, are detected in the minority of patients with RP, and are detected at similar prevalences across a spectrum of inflammatory diseases with cartilage inflammation. Use of these antibodies to diagnose or monitor RP is not advisable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.25697","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T12:59:17Z","timestamp":1763125157000},"page":"798-809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Performance Characteristics of Anti\u2013Collagen\n                    <scp>II<\/scp>\n                    Antibodies in Relapsing Polychondritis and Related Diseases: Prospective Analysis, Systematic Review, and Meta\u2010Analysis"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2409-7475","authenticated-orcid":false,"given":"Karyssa","family":"Stonick","sequence":"first","affiliation":[{"name":"National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela 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Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8269-9438","authenticated-orcid":false,"given":"Peter C.","family":"Grayson","sequence":"additional","affiliation":[{"name":"National Institutes of Health  Bethesda 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