{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:16:47Z","timestamp":1785457007683,"version":"3.56.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23AR081424A"],"award-info":[{"award-number":["K23AR081424A"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AR076316"],"award-info":[{"award-number":["P30AR076316"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["2KL2TR001426\u201005A1"],"award-info":[{"award-number":["2KL2TR001426\u201005A1"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["2UL1TR001425\u201005A1"],"award-info":[{"award-number":["2UL1TR001425\u201005A1"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to validate the Pediatric Arthritis Ultrasound Scoring System (PAUSS) for upper extremity joints in children with juvenile idiopathic arthritis (JIA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children with JIA were evaluated for elbow, wrist, or finger arthritis by clinical examination (CE) and musculoskeletal ultrasound (MSUS) with images scored according to the joint\u2010specific PAUSS. A subset of children received contrast\u2010enhanced magnetic resonance imaging (ceMRI) of the affected joint(s). The performance of the PAUSS as a measure of arthritis activity was compared to CE and ceMRI, using ceMRI as the reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010five children contributed 44 elbows, 55 wrists, and 106 fingers for MSUS and 15 elbows, 16 wrists, and 40 fingers for ceMRI. B\u2010mode PAUSS scores for the finger joints demonstrated moderate correlations with CE findings of arthritis, and the PAUSS\u2010elbow noted a strong correlation. PAUSS scores for all joints showed a sensitivity of 75% to 94% in detecting synovitis when compared to ceMRI and good to excellent diagnostic accuracy for elbow and finger arthritis. The addition of MSUS to CE markedly improved the sensitivity of CE to 92% to 100%. The PAUSS and ceMRI scores for assessment of disease severity had strong correlation for each specific joint (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.65\u20130.84,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2264\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is moderate to high sensitivity and diagnostic accuracy of the PAUSS in detecting synovitis in elbow, wrist, and finger joints, as well as a strong correlation of the PAUSS severity scores with the ceMRI severity scores, providing strong support that the PAUSS enhances the clinical assessment of disease activity in children with JIA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.25702","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:39:46Z","timestamp":1764308386000},"page":"905-913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Validation of the Pediatric Arthritis Ultrasound Scoring System for the Elbow, Wrist, and Finger Joints in Children With Juvenile Idiopathic Arthritis"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-7256","authenticated-orcid":false,"given":"Patricia","family":"Vega\u2010Fernandez","sequence":"first","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7469-109X","authenticated-orcid":false,"given":"Pinar Ozge","family":"Avar\u2010Aydin","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Rogers","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1604-0130","authenticated-orcid":false,"given":"Daniel J.","family":"Lovell","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Huggins","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Grom","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-2987","authenticated-orcid":false,"given":"Hermine I.","family":"Brunner","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-7051","authenticated-orcid":false,"given":"Grant S.","family":"Schulert","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9552-6464","authenticated-orcid":false,"given":"Sheila T.","family":"Angeles\u2010Han","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mekibib","family":"Altaye","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Cassedy","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5785-0861","authenticated-orcid":false,"given":"Arthur B.","family":"Meyers","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy V.","family":"Ting","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25438"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41879"},{"issue":"12","key":"e_1_2_6_4_1","first-page":"2331","article-title":"Reliability of the articular examination in children with juvenile rheumatoid arthritis: interobserver agreement and sources of disagreement","volume":"22","author":"Guzm\u00e1n J","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead151"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002750"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207892"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2020.101629"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-023-05815-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010091"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-023-00895-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22670"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-018-4233-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2017-000642"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-018-0240-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa804"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22410"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2023.105538"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25159"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2021.09.009"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24759"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-001581"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-eular.6199"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.220382"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket148"},{"issue":"2","key":"e_1_2_6_26_1","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.126862"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.131081"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24757"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161433"},{"issue":"6","key":"e_1_2_6_31_1","first-page":"1385","article-title":"OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA\u2010MRI scoring system","volume":"30","author":"\u00d8stergaard M","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.068361"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012"},{"issue":"3","key":"e_1_2_6_34_1","first-page":"69","article-title":"Statistics corner: a guide to appropriate use of correlation coefficient in medical research","volume":"24","author":"Mukaka MM","year":"2012","journal-title":"Malawi Med J"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181ec173d"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3108-x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25073"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex036"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1904"},{"issue":"4","key":"e_1_2_6_40_1","first-page":"839","article-title":"Summary findings of a systematic review of the ultrasound assessment of synovitis","volume":"34","author":"Joshua F","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201049"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.171246"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.25702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.25702","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.25702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:20:26Z","timestamp":1782746426000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.25702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/acr.25702"],"URL":"https:\/\/doi.org\/10.1002\/acr.25702","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]},"assertion":[{"value":"2025-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}