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Cox regression models were used to evaluate associations between sex and treatment discontinuation, adjusting for sociodemographic and clinical factors. We also examined medication continuation by sex and age group (18\u201364 vs \u226565 years) using Kaplan\u2010Meier curves and tested for interactions between sex and age, race, and area deprivation index (ADI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 7,200 individuals, the mean \u00b1 SD age was 52.7 \u00b1 14.7 years; 58.3% were female and 68.7% were non\u2010Hispanic White. Among TNFi users (N\u00a0=\u00a06,256), women had a 24% higher risk of discontinuation compared to men (hazard ratio [HR]: 1.24; 95% confidence interval [CI]: 1.16\u20131.32). Among IL\u201017i users (n\u00a0=\u00a0693), women had a 25% higher risk of discontinuation (HR: 1.25; 95% CI: 1.01\u20131.54). No significant sex differences were observed among JAKi users (N\u00a0=\u00a0251). Among TNFi users, women under 65 years had the lowest probability of treatment continuation. There was no statistically significant interaction between sex and age, race or ADI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a large US registry, women with axSpA were more likely to discontinue TNFi and IL\u201017i than men. Larger studies with longer follow\u2010up since treatment approval are needed to confirm the lack of sex differences in JAKi discontinuation as this group could be underpowered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.70001","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T06:25:17Z","timestamp":1764656717000},"page":"914-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex Differences in Medication Discontinuation in Axial Spondyloarthritis"],"prefix":"10.1002","volume":"78","author":[{"given":"Rachael","family":"Stovall","sequence":"first","affiliation":[{"name":"University of Washington  Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinthia","family":"Blat","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8435-8994","authenticated-orcid":false,"given":"Eric","family":"Roberts","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean W.","family":"Liew","sequence":"additional","affiliation":[{"name":"Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8707-7649","authenticated-orcid":false,"given":"Katherine","family":"Wysham","sequence":"additional","affiliation":[{"name":"University of Washington  Seattle"},{"name":"VA Puget Sound Health Care System  Seattle 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