{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:34:02Z","timestamp":1785537242785,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002377"],"award-info":[{"award-number":["UL1 TR002377"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG058738"],"award-info":[{"award-number":["AG058738"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K24 AG078179\u201002"],"award-info":[{"award-number":["K24 AG078179\u201002"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG068192"],"award-info":[{"award-number":["R01 AG068192"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR46849"],"award-info":[{"award-number":["R01 AR46849"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this study was to determine the cumulative incidence of diagnosis switching, drug\u2010free remission, and initiation of a biologic or targeted synthetic disease\u2010modifying antirheumatic drug (b\/tsDMARD) in individuals with seronegative rheumatoid arthritis (RA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult residents of Olmsted County, Minnesota, with incident seronegative (rheumatoid factor negative\/anti\u2013cyclic citrullinated peptide antibody negative) RA meeting the 1987 and\/or 2010 American College of Rheumatology classification criteria were included. Data were collected from January 1, 2005, to December 31, 2023, through manual chart review. Drug\u2010free remission was defined as a period of at least six months where the individual was no longer taking treatment for RA and did not have evidence of active inflammatory arthritis upon evaluation by a rheumatologist. We calculated the 10\u2010year cumulative incidence of a change in diagnosis, adjusting for the competing risk of death, and of drug\u2010free remission and initiation of a b\/tsDMARD, adjusting for the competing risks of death or change in diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 176 individuals with seronegative RA (68% women) were included. The 10\u2010year cumulative incidence of a change in diagnosis was 12.8% (95% confidence interval [CI] 8.7%\u201318.9%). The most common change in diagnosis was to spondyloarthritis (4%). The 10\u2010year cumulative incidence of drug\u2010free remission and initiation of a b\/tsDMARD was 26.6% (95% CI 20.7%\u201334.2%) and 19.9% (95% CI 14.7%\u201326.9%), respectively. Over a median follow\u2010up of 11.8 years, 49 individuals entered drug\u2010free remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>After initial diagnosis of seronegative RA, about 13% of individuals had a change in diagnosis and a quarter experienced drug\u2010free remission within 10 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.70011","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T01:30:01Z","timestamp":1765589401000},"page":"998-1005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Term Outcomes in Seronegative Rheumatoid Arthritis"],"prefix":"10.1002","volume":"78","author":[{"given":"Bradly A.","family":"Kimbrough","sequence":"first","affiliation":[{"name":"Mayo Clinic College of Medicine and Science  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roslin Jose","family":"George","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5847-7475","authenticated-orcid":false,"given":"Cynthia S.","family":"Crowson","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara J.","family":"Achenbach","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-3134","authenticated-orcid":false,"given":"Vanessa L.","family":"Kronzer","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9710-8143","authenticated-orcid":false,"suffix":"III","given":"John M.","family":"Davis","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2006-1436","authenticated-orcid":false,"given":"Elena","family":"Myasoedova","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/go7g26"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.204"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003296"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.05.023"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208873"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.124"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212386"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221754"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03050-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.939265"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215843"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac294"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140082"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.07.004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab398"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216694"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217609"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25231"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1909-8"},{"issue":"1","key":"e_1_2_6_21_1","first-page":"37","article-title":"Does early seronegative arthritis develop into rheumatoid arthritis? 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