{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:21:22Z","timestamp":1787757682362,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is a chronic autoimmune condition that can lead to death. To examine SLE as an underlying and contributing cause of death, the Centers for Disease Control and Prevention (CDC) analyzed 2018 to 2023 mortality data for persons aged \u226515 years overall and by age, sex, race and ethnicity, and region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Death certificate data for persons aged \u226515 years with any mention of SLE (\n                      <jats:italic>International Classification of Diseases, Tenth Revision<\/jats:italic>\n                      [ICD\u201010] code M32) were analyzed using the CDC Wide\u2010ranging Online Data for Epidemiologic Research (WONDER) system. We calculated age\u2010adjusted death rates and assessed patterns by sex, age, race and ethnicity, and region. Underlying and contributing causes of death were evaluated using ranked cause\u2010of\u2010death lists and ICD\u201010 subchapters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During 2018 to 2023, 14,936 deaths had any mention of SLE listed on the death certificates. Of these deaths, 6,414 (42.9%) listed SLE as the underlying cause. The age\u2010adjusted SLE mortality rate per million population was greater among females (5.97) than males (1.16), non\u2010Hispanic African American persons (10.70) than persons of other non\u2010Hispanic racial groups (range 2.46\u20135.62), Hispanic persons (3.98) than non\u2010Hispanic persons (3.59), and people in the South (4.37) than people in other regions. When SLE was listed as a contributing cause of death, the leading underlying causes were heart disease (0.93), cancer (0.56), and COVID\u201019 (0.51). The overall age\u2010adjusted SLE mortality rates were significantly higher in 2020 and 2021 than in all other study years, indicating the likely impact of the COVID\u201019 pandemic on SLE mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall management of SLE, comorbidities, and infections in patients with SLE, as well as interventions targeting groups (eg, African American persons) disproportionately impacted by SLE, may reduce overall SLE mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.70042","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T14:27:15Z","timestamp":1768228035000},"page":"1188-1194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic Lupus Erythematosus Mortality Among Decedents Aged \u226515 Years\u2014United States, 2018\u20132023"],"prefix":"10.1002","volume":"78","author":[{"given":"Danielle","family":"Dawson","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia"},{"name":"Oak Ridge Institute for Science and Education  Oak Ridge Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt J.","family":"Greenlund","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil E.","family":"Barbour","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41632"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-009-8192-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/09612033241257134"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25509"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-0102"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.70057"},{"issue":"20","key":"e_1_2_6_8_1","first-page":"1","article-title":"Age adjustment using the 2000 projected U.S. population","author":"Klein RJ","year":"2001","journal-title":"Healthy People 2000 Stat Notes"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1198\/000313001317097960"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.15620\/cdc\/147882"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24988"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00296-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2022-000750"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-015-0043-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170953"},{"key":"e_1_2_6_16_1","unstructured":"Centers for Disease Control and Prevention.How to protect yourself and others. March 10 2025. Accessed August 6 2025.https:\/\/www.cdc.gov\/covid\/prevention\/index.html"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.70042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.70042","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.70042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:49:59Z","timestamp":1787755799000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.70042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/acr.70042"],"URL":"https:\/\/doi.org\/10.1002\/acr.70042","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]},"assertion":[{"value":"2025-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}