{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:30:54Z","timestamp":1792132254966,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX002807"],"award-info":[{"award-number":["BX002807"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK2 CX002351"],"award-info":[{"award-number":["IK2 CX002351"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K23AR079588"],"award-info":[{"award-number":["K23AR079588"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["PC170059"],"award-info":[{"award-number":["PC170059"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG061558"],"award-info":[{"award-number":["R01AG061558"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA239208"],"award-info":[{"award-number":["R01CA239208"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA279220"],"award-info":[{"award-number":["R01CA279220"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R03AG082857"],"award-info":[{"award-number":["R03AG082857"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Frailty occurs prematurely in rheumatoid arthritis (RA) and is associated with poor health outcomes. We compared the performance of four frailty instruments, including a pragmatic alternative measure using chair sit\u2010to\u2010stand (STS), and evaluated their abilities to predict poor health outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Frailty was measured at baseline using four instruments: the Fried Frailty Phenotype with STS (Fried\u2010STS), the Fried Frailty Phenotype with hand grip strength (Fried\u2010HGS), the Veterans Affairs Frailty Index (VA\u2010FI), and the FRAIL Scale. Outcomes collected at the one\u2010year follow\u2010up included category of falls (none, one, more than one), category of days hospitalized (none, one to three, more than three), and a composite outcome of fall, hospitalization, or death. Ordinal logistic or logistic regression models, adjusted for age and sex, explored the association of frailty and each outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 143 participants were included (mean \u00b1 SD age 64.5\u2009\u00b1\u200911.7 years, 73% male, and 69% White). Categorization as frail differed by instrument: Fried\u2010STS, 17%; Fried\u2010HGS, 15%; VA\u2010FI, 36%; and FRAIL Scale, 20%. There was poor agreement between frailty instruments (k\u00a0=\u00a00.07\u20130.31) except for the Fried\u2010STS and Fried\u2010HGS (k\u00a0=\u00a00.62). Frailty by the Fried\u2010STS, Fried\u2010HGS, and FRAIL Scale was associated with falls (adjusted odds ratios [aORs] 3.83\u20139.54,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Frailty by the VA\u2010FI was associated with days hospitalized (aOR 5.21,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.017). Frailty by the Fried\u2010STS, VA\u2010FI, and FRAIL Scale was associated with higher odds of the composite measure of incident fall, hospitalization, or death (aORs 2.93\u20137.25,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Each frailty measure predicted adverse health outcomes, with phenotypic and patient\u2010reported measures predicting falls and the deficit accumulation model predicting hospitalization days. Being frail by the Fried\u2010HGS did not predict poor outcomes as well as the other frailty instruments, including the Fried\u2010STS.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/acr80013-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.80013","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:29:40Z","timestamp":1770614980000},"page":"1167-1176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluating a Pragmatic Strength Alternative for Frailty Measurement and Assessing Its Predictive Capacity Against Established Frailty Instruments in Rheumatoid Arthritis"],"prefix":"10.1002","volume":"78","author":[{"given":"Kylie E.","family":"Riggles","sequence":"first","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1964-5318","authenticated-orcid":false,"given":"Hannah F.","family":"Brubeck","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5358-8328","authenticated-orcid":false,"given":"Adrienne D.","family":"Tanus","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney N.","family":"Loecker","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center  Omaha"},{"name":"VA Nebraska\u2010Western Iowa Health Care System  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punyasha","family":"Roul","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-3588","authenticated-orcid":false,"given":"Bryant R.","family":"England","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center  Omaha"},{"name":"VA Nebraska\u2010Western Iowa Health Care System  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Wahl","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington"},{"name":"University of Washington School of Medicine  Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Andrews","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"},{"name":"Birmingham VA Health Care System  Birmingham Alabama"},{"name":"Birmingham\/Atlanta VA Geriatrics Research Education and Clinical Center  Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata","family":"Singh","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine  Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua F.","family":"Baker","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center  Philadelphia Pennsylvania"},{"name":"University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8146-2519","authenticated-orcid":false,"given":"Patricia P.","family":"Katz","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores M.","family":"Shoback","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"},{"name":"San Francisco VA Medical Center  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Garcia","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington"},{"name":"University of Washington School of Medicine  Seattle"},{"name":"VA Puget Sound Geriatric Research Education and Clinical Center  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariela R.","family":"Orkaby","sequence":"additional","affiliation":[{"name":"New England Geriatric Research, Education, and Clinical Center  Boston Massachusetts"},{"name":"VA Boston Healthcare System  Boston Massachusetts"},{"name":"Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine D.","family":"Wysham","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington"},{"name":"University of Washington School of Medicine  Seattle"},{"name":"VA Puget Sound Geriatric Research Education and Clinical Center  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2301292"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11640"},{"issue":"4","key":"e_1_2_6_5_1","first-page":"585","article-title":"Frailty in seropositive rheumatoid arthritis patients of working age: a cross\u2010sectional study","volume":"37","author":"Haider S","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/1kr7bs"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2022.105343"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218282"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24747"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.17208.2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12420"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-020-00017-z"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2001.58"},{"issue":"8","key":"e_1_2_6_15_1","first-page":"1407","article-title":"The prevalence and meaning of fatigue in rheumatic disease","volume":"23","author":"Wolfe F","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.5606\/tjr.2013.2742"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/IES-2010-0389"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2021.11.007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2020.07.016"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.443"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly232"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982161"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.13061"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537606"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afz046"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199910)42:10<2220:AID-ANR26>3.0.CO;2-5"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_6_30_1","volume-title":"Stata Statistical Software: Release 18","year":"2023"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23784"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25615"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-21533-5"},{"issue":"3","key":"e_1_2_6_34_1","first-page":"523","article-title":"Validation of two frailty questionnaires in older patients with rheumatoid arthritis: a cross\u2010sectional study","volume":"38","author":"Oetsma S","year":"2020","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.23750\/abm.v91i2.9094"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.06.006"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-002111"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2007.11.005"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.19268"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.80013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.80013","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/acr.80013","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.80013","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.80013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:49:27Z","timestamp":1787755767000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.80013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,7]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/acr.80013"],"URL":"https:\/\/doi.org\/10.1002\/acr.80013","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,7]]},"assertion":[{"value":"2025-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}