{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:49:01Z","timestamp":1791607741404,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG18820"],"award-info":[{"award-number":["AG18820"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG18832"],"award-info":[{"award-number":["AG18832"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG18947"],"award-info":[{"award-number":["AG18947"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG19069"],"award-info":[{"award-number":["AG19069"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01 AR06972"],"award-info":[{"award-number":["K01 AR06972"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MOST4 U19 AG076471"],"award-info":[{"award-number":["MOST4 U19 AG076471"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AR0702571"],"award-info":[{"award-number":["P30 AR0702571"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03AG060272"],"award-info":[{"award-number":["R03AG060272"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AR074578"],"award-info":[{"award-number":["R21AR074578"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Gait affects knee loading. Modifying gait could reduce load and protect against cartilage loss. Our objective is to look for modifiable gait parameters and determine their relation to worsening cartilage damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied participants from the Multicenter Osteoarthritis Study (MOST) ages 45 to 90 years with, or at risk for, knee osteoarthritis (OA). Gait assessment used inertial measurement units (APDM, Inc) on the pelvis and ankles during a 20\u2010m walk. Knee magnetic resonance imaging (MRI) was acquired at baseline and two years later. Cartilage damage worsening was assessed using MRI Osteoarthritis Knee Scores in 14 knee subregions. We examined change (yes\/no) in each subregion. We used ensemble machine learning to discriminate subregions with and without cartilage damage. Predictors tested included gait variables, radiographic OA, baseline cartilage damage, age, sex, height, weight, depressive symptoms, and race\/clinic site. Data were split 70% training and 30% test sets. We identified the 10 variables that, across 100 repetitions, most frequently contributed to risk of damage. We used G\u2010computation to evaluate causal risk differences of worsening cartilage damage for each variable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We studied 1,703 participants (mean [\u00b1SD] age 61.4 [\u00b19.4] years, 56% female). At two years, 46% had worse cartilage damage in at least one knee subregion. Of gait variables, longer step length was associated with increased risk of damage, especially in knees with more baseline damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Longer step length was associated with worse cartilage damage over two years. Interventions to shorten step length might reduce risk of worsening cartilage damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.80018","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:10:41Z","timestamp":1770991841000},"page":"1229-1238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Wearable Sensor\u2013Derived Gait Measures With Cartilage Damage Over Two Years Among Adults With or at Risk of Knee Osteoarthritis"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3146-4831","authenticated-orcid":false,"given":"Kathryn L.","family":"Bacon","sequence":"first","affiliation":[{"name":"Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2668-2447","authenticated-orcid":false,"given":"David T.","family":"Felson","sequence":"additional","affiliation":[{"name":"Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-9175","authenticated-orcid":false,"given":"S. Reza","family":"Jafarzadeh","sequence":"additional","affiliation":[{"name":"Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Hausdorff","sequence":"additional","affiliation":[{"name":"Tel Aviv University  Tel Aviv Israel"},{"name":"Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Rush University Medical Center  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Gazit","sequence":"additional","affiliation":[{"name":"Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[{"name":"Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W.","family":"Roemer","sequence":"additional","affiliation":[{"name":"Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts"},{"name":"Universit\u00e4tsklinikum Erlangen  Erlangen Germany"},{"name":"Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8294-080X","authenticated-orcid":false,"given":"Neil A.","family":"Segal","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center  Kansas City"},{"name":"The University of Iowa  Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora E.","family":"Lewis","sequence":"additional","affiliation":[{"name":"The University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Nevitt","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1728-484X","authenticated-orcid":false,"given":"Deepak","family":"Kumar","sequence":"additional","affiliation":[{"name":"Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts"},{"name":"Boston University  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Multicenter Osteoarthritis Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.10.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41142"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/s20247143"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2196\/33521"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2022.09.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24783-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02045-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8164-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2016.2636456"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25327"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.05.004"},{"key":"e_1_2_6_14_1","article-title":"Walking cadence to exercise at moderate intensity for adults: a systematic review","volume":"2017","author":"Slaght J","year":"2017","journal-title":"J Sports Med (Hindawi Publ Corp)"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(03)00233-1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-006-0676-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3147408"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2009.06.004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-007-0955-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968311424869"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2011.07.024"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39848"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-21142-2"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23754"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22693"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/19476035221147677"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.07.012"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_2_6_30_1","volume-title":"sl3: Pipelines for Machine Learning and Super Learning","author":"Coyle JR","year":"2021"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-6080(05)80023-1"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2022-106142"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq472"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217363"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2015.12.040"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.4085\/1062-6050-0186.21"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25001"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2010.01.016"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2017.03.004"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humov.2020.102611"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2023.05.025"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4046713"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2023.111449"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22738"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2023.11.022"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-021-02634-4"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.01.010"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNB.2018.2840082"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.08.003"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.80018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.80018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.80018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:50:04Z","timestamp":1787755804000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.80018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/acr.80018"],"URL":"https:\/\/doi.org\/10.1002\/acr.80018","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]},"assertion":[{"value":"2025-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}