{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T08:12:18Z","timestamp":1779264738843,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K24AR074534"],"award-info":[{"award-number":["K24AR074534"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30AR070155"],"award-info":[{"award-number":["P30AR070155"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Individuals with systemic lupus erythematosus (SLE) can accumulate functional status (FS) impairment. We evaluated the association between neighborhood socioeconomic disadvantage, as measured by the Area Deprivation Index (ADI), and FS in a national SLE sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were derived from Rheumatology Informatics System for Effectiveness, a national electronic health record\u2013based registry. Individuals aged \u226518 years old with at least two visits for SLE \u226530 days apart and at least one FS assessment measure in 2016 to 2022 were included. ADI was grouped into quintiles. Cross\u2010sectionally, mean FS scores were compared across ADI quintiles, and multilevel regression models were used to examine the association between ADI and FS score. Similarly, a multilevel model was used to assess the association between ADI and FS decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean (\u00b1SD) age in the cross\u2010sectional cohort (N\u00a0=\u00a020,620) was 56.0 (\u00b115.5) years; 91.4% were female, and 57.6% were non\u2010Hispanic White. Baseline characteristics were similar in the longitudinal cohort (N\u00a0=\u00a010,604). Adjusted mean FS scores (interquartile range [IQR]) were higher (worse) among those with higher ADI (ADI quintile 1 [highest socioeconomic status (SES)]: 1.53 [1.28\u20131.77]; quintile 5 [lowest SES]: 1.90 [1.63\u20132.16]). In the longitudinal cohort, 15.7% experienced FS decline. The proportion of patients with FS decline (IQR) was greater with decreases in ADI (quintile 1: 11.4% [9.3%\u201313.5%]; quintile 5: 17.0% [13.7%\u201320.2%]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this national sample of adults with SLE, greater neighborhood deprivation was associated with worse physical function and a higher likelihood of short\u2010term functional decline. Clinical efforts to improve outcomes should include routine assessment of function and patient\u2010centered interventions that acknowledge and help mitigate social and structural barriers to health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.80074","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:48:18Z","timestamp":1777542498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neighborhood Socioeconomic Status and Short\u2010Term Functional Outcomes in Systemic Lupus Erythematosus"],"prefix":"10.1002","author":[{"given":"Baljeet","family":"Rai","sequence":"first","affiliation":[{"name":"University of Southern California  Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3298-2112","authenticated-orcid":false,"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8435-8994","authenticated-orcid":false,"given":"Eric","family":"Roberts","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8146-2519","authenticated-orcid":false,"given":"Patricia","family":"Katz","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-8981","authenticated-orcid":false,"given":"Laura","family":"Plantinga","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2687-5043","authenticated-orcid":false,"given":"Gabriela","family":"Schmajuk","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"},{"name":"San Francisco VA Medical Center  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3508-4094","authenticated-orcid":false,"given":"Jinoos","family":"Yazdany","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40512"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00296-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25359"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2009.12.006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24040"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2016.01.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22399"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20409"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23507"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25266"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh376"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.04.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25301"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.190991"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02784.x"},{"issue":"9","key":"e_1_2_6_17_1","first-page":"1782","article-title":"The role of neighborhood and individual socioeconomic status in outcomes of systemic lupus erythematosus","volume":"35","author":"Trupin L","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23089"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199910)42:10<2220:AID-ANR26>3.0.CO;2-5"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-20"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20549"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20620"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.4501"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26185"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.02.016"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2946"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(92)90133-8"},{"key":"e_1_2_6_28_1","volume-title":"STATA Multiple\u2010Imputation Reference Manual Release 19","year":"2021"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315591621"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40134"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23428"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200104)45:2<191:AID-ANR173>3.0.CO;2-2"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1475-6773.13092"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.2355"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12039"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-020-2123-4"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23588"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3492-6"},{"key":"e_1_2_6_39_1","article-title":"A review of potential adverse effects of long\u2010term opioid therapy: a practitioner's guide","volume":"14","author":"Baldini A","year":"2012","journal-title":"Prim Care Companion CNS Disord."},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6838a2"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11590"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/09612033231157073"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare9091215"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/09612033221083273"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14197031"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2024-004171"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2024-001317"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.191187"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy181"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2022.01406"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/haschl\/qxad063"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.80074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.80074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.80074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:46:45Z","timestamp":1779263205000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.80074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":50,"alternative-id":["10.1002\/acr.80074"],"URL":"https:\/\/doi.org\/10.1002\/acr.80074","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"assertion":[{"value":"2025-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"acr.80074"}}