{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:15:26Z","timestamp":1784621726783,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective is to describe and compare demographic, clinical, and serological characteristics of patients with systemic sclerosis (SSc) according to ethnic background.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants enrolled in the Canadian Scleroderma Research Group cohort who self\u2010identified to a single ethnicity group were included. Baseline characteristics were compared using analysis of variance, chi\u2010square, or Kruskal\u2010Wallis rank sum test. Kaplan\u2010Meier curves and Cox regression were used to estimate mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1,477 eligible participants, 1,345 (91.1%) identified as White, 55 (3.7%) as Indigenous, 22 (1.5%) as East\/Southeast Asian, 20 (1.4%) as Middle Eastern, 16 (1.1%) as Black, 12 (0.8%) as South Asian, and 7 (0.5%) as Latin American. White individuals had a lower prevalence of diffuse cutaneous SSc (33% vs 53%) and telangiectasias (44% vs 67%) compared with other ethnicities. Conversely, Black individuals had a higher prevalence of myositis (44% vs 10%), higher mean modified Rodnan skin score (18.4 vs 9.6), lower mean forced vital capacity (73.7% predicted vs 92.9% predicted) and DL\n                      <jats:sc>co<\/jats:sc>\n                      values (54.5% predicted vs 70.6% predicted), and the lowest survival probabilities at one (85%) and five years (57%). Indigenous individuals had the highest prevalence of anti\u2010RNA polymerase III antibodies (34% vs 19%) and were more frequently affected by lower gastrointestinal manifestations. East\/Southeast Asian individuals were the least frequently affected by Raynaud phenomenon (90%) and digital ulcers (29%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ethnicity was associated with distinct SSc phenotypes. These differences provide prognostic information that can guide screening and management strategies, thus representing an opportunity to personalize care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.80098","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:31:21Z","timestamp":1780317081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7534-6553","authenticated-orcid":false,"given":"Danick","family":"Goulet","sequence":"first","affiliation":[{"name":"Centre de recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montreal Quebec 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