{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:14:56Z","timestamp":1788333296254,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["539914"],"award-info":[{"award-number":["539914"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to test the hypothesis that multijoint osteoarthritis would modify the relation between time and frailty progression, in which more affected joints would lead to larger declines over six years compared to those without osteoarthritis using data from the Canadian Longitudinal Study on Aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Frailty was quantified using a frailty index at baseline, three\u2010year, and six\u2010year follow\u2010up. Osteoarthritis was self\u2010reported physician diagnosis of knee, hip, or hand. Participants were categorized as having none, one, two, or three affected joints at baseline. Linear mixed\u2010effects models adjusted for age, body mass index, marital status, sitting time, light\u2013moderate physical activity, strenuous physical activity, and sex were performed to test the interaction between time and multijoint osteoarthritis on frailty trajectories over six years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 13,757 participants were included (mean frailty: 0.16\u2009\u00b1\u20090.05); 10,193 had no osteoarthritis, 2,535 had one affected joint, 806 had two affected joints, and 223 had three affected joints. Individuals without osteoarthritis had the lowest baseline frailty, followed stepwise by the one\u2010joint group, two\u2010joint group, and three\u2010joint group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Baseline multijoint osteoarthritis was positively associated with frailty progression over six years (\u03b2\u00a0=\u00a00.105, 95% confidence interval [CI] 0.027\u20130.170). Frailty slopes across groups were the following: no osteoarthritis (\u03b2\u00a0=\u00a00.237, 95% CI 0.225\u20130.247), one\u2010joint group (\u03b2\u00a0=\u00a00.293, 95% CI 0.262\u20130.310), two\u2010joint group (\u03b2\u00a0=\u00a00.348, 95% CI 0.327\u20130.368), and three\u2010joint group (\u03b2\u00a0=\u00a00.330, 95% CI 0.291\u20130.371). Frailty progressed faster in multijoint group (at least two joints) versus single\u2010joint osteoarthritis (\u03b2\u00a0=\u00a00.070, 95% CI 0.029\u20130.109).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Individuals with osteoarthritis affecting two or three joints experienced a 40% to 47% faster rate of frailty progression compared with those without osteoarthritis despite starting at a higher baseline frailty, highlighting multijoint involvement as a marker of heightened risk of accumulating health deficits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.80139","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:55:26Z","timestamp":1786964126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Individuals With Multijoint Osteoarthritis Demonstrate Larger Longitudinal Declines in Frailty: Data From the Canadian Longitudinal Study on Aging"],"prefix":"10.1002","author":[{"given":"Carson","family":"Halliwell","sequence":"first","affiliation":[{"name":"Department of Human Kinetics, Faculty of Science St. Francis Xavier University  Antigonish Nova Scotia Canada"},{"name":"Centre de Formation M\u00e9dicale du Nouveau\u2010Brunswick  Moncton New Brunswick Canada"},{"name":"Department of Medicine, Faculty of Medicine and Health Science Sherbrooke University  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1719-4799","authenticated-orcid":false,"given":"Rebecca","family":"Moyer","sequence":"additional","affiliation":[{"name":"School of Physiotherapy, Faculty of Health Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0665-5062","authenticated-orcid":false,"given":"Myles W.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Centre de Formation M\u00e9dicale du Nouveau\u2010Brunswick  Moncton New Brunswick Canada"},{"name":"Department of Medicine, Faculty of Medicine and Health Science Sherbrooke University  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216515"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-025-01332-8"},{"issue":"5","key":"e_1_2_7_4_1","first-page":"3","article-title":"Osteoarthritis is a serious disease","volume":"37","author":"Hawker GA","year":"2019","journal-title":"Clin Exp 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