{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:18:26Z","timestamp":1788239906490,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ1015"],"award-info":[{"award-number":["2024JJ1015"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ3047"],"award-info":[{"award-number":["2024JJ3047"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hand synovitis affects over 20% middle\u2010aged and older adults. Although the roles of synovitis in hand pain and osteoarthritis are well established, its relationship with serious outcomes such as mortality remains uncertain. We investigated the association between hand synovitis and all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the population\u2010based Xiangya Osteoarthritis Study (XO Study), participants underwent bilateral hand ultrasonography at baseline to assess synovitis (grades 0\u20133; \u22652 defined as positive). Mortality data were obtained from local registries. Cox proportional hazards models were employed to examine the association between hand synovitis and all\u2010cause mortality, adjusting for age, age squared, sex, body mass index, educational level, alcohol consumption, smoking status, hand injury, physical activity level, radiographic hand osteoarthritis status, hypertension, hyperlipidemia, and the age\u2010adjusted Charlson Comorbidity Index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 3,552 participants (mean\u2009\u00b1\u2009SD age 64.4\u2009\u00b1\u20099.3 years, 57.9% women), 393 deaths occurred over a mean follow\u2010up of 5.72 years. Ultrasound\u2010detected hand synovitis was significantly associated with higher all\u2010cause mortality (adjusted hazard ratio [aHR] 1.26, 95% confidence interval [CI] 1.01\u20131.58). Compared with no synovitis, bilateral involvement conferred a higher mortality than unilateral involvement (aHR 1.42 [95% CI 1.03\u20131.96] versus 1.20 [95% CI 0.93\u20131.54]). Mortality risk also increased with the number of affected joints (aHRs: 1.19 [95% CI 0.91\u20131.57] for one joint; 1.35 [95% CI 1.02\u20131.80] for more than one joint;\n                      <jats:italic>P<\/jats:italic>\n                      for trend &lt; 0.05). In the exploratory analyses, the strongest association was observed for distal interphalangeal joint synovitis (aHR 1.82 [95% CI 1.14\u20132.91]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hand synovitis, especially when bilateral or polyarticular, may serve as a marker of increased all\u2010cause mortality risk, though future studies are needed to confirm and investigate this further. Ultrasound assessment offers a noninvasive and accessible approach to identify this potential biomarker for mortality risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.80141","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:42:38Z","timestamp":1786970558000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Hand Synovitis and All\u2010Cause Mortality: A General Population\u2010Based Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2465-6218","authenticated-orcid":false,"given":"Ke","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopedics Xiangya Hospital, Central South University  Changsha 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 Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6597-870X","authenticated-orcid":false,"given":"Qiu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9488-7478","authenticated-orcid":false,"given":"Cheng","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9468-4110","authenticated-orcid":false,"given":"Yilun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Xiangya Hospital, Central South University  Changsha 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