{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:07:25Z","timestamp":1789542445451,"version":"build-2803163510"},"reference-count":0,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"abstract":"\n Objective<\/jats:title>\n We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry, an ongoing prospective registry\u2010based cohort study. At every clinic visit, clinicians reported AAEs since the previous visit, their severity and actions undertaken. We calculated proportion of patients and visits with an event, events rates per 100 patient\u2010years (PY), and used Kaplan\u2010Meir and Cox regression analysis to estimate first AAE risk and assess associated risk factors.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among 964 patients followed for 2,046 PY, AAEs occurred in 39.0% of patients (34.9 per 100PY) and SAEs in 3.4% (2.0 per 100PY). Gastrointestinal symptoms linked to non\u2010steroidal anti\u2010inflammatory drugs (NSAID) and methotrexate (MTX) were most common (56.4%). In adjusted analyses, active disease, subcutaneous MTX (HR 3.27, p<0.001), oral MTX (HR 2.08, p<0.001), and NSAID (HR 2.17, p<0.001) were associated with increased AAE risk, while biologic Disease Modifying Anti\u2010Rheumatic Drugs (bDMARDs) were associated with decreased risk (HR 0.46, p<0.001). Forty SAEs occurred, including 16 infections with hospitalization and one malignancy, mostly in patients not receiving bDMARDs. There were no deaths, demyelinating conditions, or opportunistic infections.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In this real\u2010practice JIA cohort, AAEs were reported in 2 of 5 patients and most were mild events related to NSAID and MTX. SAEs were rare with no deaths and few major complications.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acr.80162","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:21:21Z","timestamp":1789384881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence, Risk Factors and Management of Adverse Events in Contemporary Real\u2010World Care of Children with Juvenile Idiopathic Arthritis"],"prefix":"10.1002","author":[{"given":"Bashayer","family":"Alnuaimi","sequence":"first","affiliation":[{"name":"Division of Pediatric Rheumatology. Department of Pediatrics. McGill University. Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2780-0617","authenticated-orcid":false,"given":"Roberta A.","family":"Berard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital London Health Sciences Centre and Western University London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Proulx\u2010Gauthier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics. CHU de Qu\u00e9bec \u2010\u00a0Universit\u00e9 Laval Quebec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8142-8946","authenticated-orcid":false,"given":"Heinrike","family":"Schmeling","sequence":"additional","affiliation":[{"name":"Department of Pediatrics. University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6412-1029","authenticated-orcid":false,"given":"Michelle","family":"Batthish","sequence":"additional","affiliation":[{"name":"Department of Pediatrics McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Boire","sequence":"additional","affiliation":[{"name":"Department of Medicine Universit\u00e9 de Sherbrooke Sherbrooke QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Huber","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics Dalhousie University Halifax NS Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dax G.","family":"Rumsey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-2581","authenticated-orcid":false,"given":"Jaime","family":"Guzman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of British Columbia BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9702-7776","authenticated-orcid":false,"given":"Ga\u00eblle","family":"Ch\u00e9deville","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology. Department of Pediatrics. McGill University. Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The CAPRI registry Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"container-title":["Arthritis Care & Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.80162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.80162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:55:48Z","timestamp":1789541748000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.80162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":0,"alternative-id":["10.1002\/acr.80162"],"URL":"https:\/\/doi.org\/10.1002\/acr.80162","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]},"assertion":[{"value":"2025-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"acr.80162"}}