{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:50:17Z","timestamp":1791521417009,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24\u2010AR\u2010080840"],"award-info":[{"award-number":["K24\u2010AR\u2010080840"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Pain is a common and burdensome symptom in patients with idiopathic inflammatory myopathies (IIM). Our aim was to identify pain phenotypes in IIM that may reflect distinct underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An anonymous electronic survey of patients with self\u2010reported IIM and pain attributable to myositis was circulated. The survey included questions related to demographics, IIM\u2010related information, pain characteristics, and the Fibromyalgia Survey Questionnaire. Latent class analysis (LCA) was performed using four variables, including distribution, pattern, difference in pain during myositis flare versus now, and disease duration. Class validity was assessed using pain characteristics, fibromyalgia criteria fulfillment, and symptom burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 426 participants were included. LCA identified four classes: (i) class 1: proximal arm\u2010 and leg\u2010predominant pain and lowest persistent pain, (ii) class 2: diffuse axial and proximal limb\u2010predominant pain, (iii) class 3: diffuse axial and distal leg\u2010predominant pain, and (iv) class 4: widespread axial and extremity pain and the highest persistent pain. In post hoc analyses, class 1 primarily included participants with earlier IIM and a lower rate of fibromyalgia. Class 2 and 3 included participants with intermediate fibromyalgia symptom burden, and class 4 included participants with the highest pain intensity and fibromyalgia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this large international cohort of patients with self\u2010reported IIM and pain, we identified four different pain phenotypes. These phenotypes range from a localized, disease\u2010related nociceptive pattern to a widespread, fibromyalgia\u2010like nociplastic pattern. Our findings highlight the heterogeneity of myositis\u2010related pain and may inform future mechanistic studies and phenotype\u2010directed management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.80164","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:36:26Z","timestamp":1789468586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pain Phenotypes in Patients With Inflammatory Myopathies: A Latent Class Analysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5872-520X","authenticated-orcid":false,"given":"Mohammad","family":"Radaideh","sequence":"first","affiliation":[{"name":"Rush University Medical Center  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duaa","family":"Husein","sequence":"additional","affiliation":[{"name":"Jordan University of Science and Technology  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almurtada","family":"Razok","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5708-5971","authenticated-orcid":false,"given":"Juan","family":"Schmukler","sequence":"additional","affiliation":[{"name":"Rush University Medical Center  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Best","sequence":"additional","affiliation":[{"name":"Rush University Medical Center  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshlean","family":"Fair","sequence":"additional","affiliation":[{"name":"Rush University Medical Center  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Lubinus","sequence":"additional","affiliation":[{"name":"Myositis Support and Understanding Association  Lincoln Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2105-3393","authenticated-orcid":false,"given":"Yvonne C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Northwestern University Medical Center  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didem","family":"Saygin","sequence":"additional","affiliation":[{"name":"Rush University Medical Center  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00321-x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002591"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25571"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2024.152476"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/4msi8i"},{"key":"e_1_2_6_7_1","unstructured":"International Association for the Study of Pain.Terminology. IASP. Accessed September 27 2026.https:\/\/www.iasp-pain.org\/resources\/terminology\/"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25104"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.08.012"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S223092"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-024-00966-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2022.105399"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.107"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0091"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.2573"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(86)90026-6"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.80164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.80164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.80164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:17:40Z","timestamp":1791519460000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.80164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":15,"alternative-id":["10.1002\/acr.80164"],"URL":"https:\/\/doi.org\/10.1002\/acr.80164","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,8]]},"assertion":[{"value":"2026-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"acr.80164"}}