{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:54:48Z","timestamp":1790920488535,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to evaluate the real\u2010world effectiveness and safety of secukinumab in patients with giant cell arteritis (GCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective study included patients with GCA who received secukinumab at 14 Italian centers with at least six months of follow\u2010up. Outcomes included clinical, complete, and glucocorticoid (GC)\u2010free remission, GC dose reduction, drug retention rate, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010six patients were included (66.7% women); median age at secukinumab initiation was 74 (interquartile range [IQR] 70\u201380) years. Overall, 32 of 36 patients (88.9%) had previously relapsed and 26 of 36 (72.2%) had received tocilizumab. Clinical remission was observed in 85.2%, 80.6%, and 83.3% at 3, 6, and 12 months, respectively. Complete remission occurred in 55.6%, 52.8%, and 63.3%, whereas GC\u2010free remission increased progressively, reaching 14.8%, 27.8%, and 40.0% at 3, 6, and 12 months, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.012). Median daily GC dose decreased from 8.7 (IQR 4.0\u201321.2) mg at baseline to 0 (0\u20135.0) mg at 12 months (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001); GCs were discontinued in 12 of 28 patients (42.9%). The 12\u2010month retention rate was 77.0%. Adverse events occurred in 20 of 36 patients (55.6%); infections occurred in 18 of 36 patients (50.0%), accounting for 21 infectious episodes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this multicenter, real\u2010world cohort of patients with GCA, including those with relapsing disease and previous biologic exposure, secukinumab was associated with high observed remission rates, progressive GC dose reduction, and increasing GC\u2010free remission. Although the phase III GCAptAIN trial did not meet its primary endpoint, these findings suggest that interleukin\u201017A inhibition may warrant further evaluation in patients with GCA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.80167","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:41:25Z","timestamp":1789987285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Effectiveness and Safety of Secukinumab in Giant Cell Arteritis: An Italian Multicenter Cohort Study"],"prefix":"10.1002","author":[{"given":"Luca","family":"Iorio","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Medicine University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Davanzo","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Ricordi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Azienda USL\u2010IRCCS di Reggio Emilia  Reggio Emilia Italy"},{"name":"University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5400-2955","authenticated-orcid":false,"given":"Milena","family":"Bond","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital of Bruneck (ASAA\u2010SABES) Teaching Hospital of the Paracelsus Medical University  Brunico Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruggiero","family":"Mascolo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine ASST Fatebenefratelli\u2010Sacco  Milan 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Gemelli\u2014IRCCS  Rome Italy"},{"name":"Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pollastri","sequence":"additional","affiliation":[{"name":"Rheumatology Unit University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Vivaldelli","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital of Bruneck (ASAA\u2010SABES) Teaching Hospital of the Paracelsus Medical University  Brunico Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Marvisi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Azienda USL\u2010IRCCS di Reggio Emilia  Reggio Emilia Italy"},{"name":"University of Modena and Reggio Emilia  Modena 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