{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:49:20Z","timestamp":1791866960307,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the risk of clinically meaningful muscle\u2010 and liver\u2010related outcomes associated with concomitant colchicine\u2013statin therapy in a real\u2010world setting, and to determine whether concomitant therapy increases the incidence of toxicity compared with either agent alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective cohort study using the national Clalit Health Services database (\u22485.4 million insured individuals). Adults with gout or familial Mediterranean fever between 2010 and 2024 were categorized into four exposure groups: no treatment, colchicine only, statin only, or concomitant therapy. Propensity\u2010score matching was used to balance baseline characteristics. The primary outcome was creatine kinase (CK) elevation &gt;3\u00d7 the upper limit of normal (ULN), and secondary outcomes included alanine transaminase elevation &gt;5\u00d7 the ULN, myopathy, liver disease, and hospitalizations related to these conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eligible participants before and after propensity\u2010score matching were 104,066 and 31,839, respectively (no treatment n\u00a0=\u00a07,146; colchicine only n\u00a0=\u00a07,146; statin only n\u00a0=\u00a09,030; concomitant therapy n\u00a0=\u00a08,517). Compared with no treatment, CK elevations &gt;3\u00d7 ULN were observed with statin therapy (hazard ratio [HR] 1.64 [95% confidence interval (CI) 1.39\u20131.93]) and concomitant colchicine\u2013statin therapy (HR 1.74 [95% CI 1.44\u20132.09]) but not with colchicine therapy alone (HR 1.08 [95% CI 0.89\u20131.31]). Clinically diagnosed myopathy was infrequent and showed a graded increase across exposure groups, with the highest risk observed in the concomitant treatment group (HR 1.50 [95% CI 1.31\u20131.72]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although colchicine\u2013statin concomitant therapy was associated with higher rates of laboratory and clinical adverse events, the additional risk beyond statin monotherapy was small, supporting their use when clinically indicated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.80172","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T10:13:49Z","timestamp":1790590429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Safety of Concomitant Colchicine and Statin Therapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6462-8380","authenticated-orcid":false,"given":"Roni","family":"Meidan","sequence":"first","affiliation":[{"name":"Department of Rheumatology Tel Aviv Sourasky University Medical Center (Ichilov)  Tel Aviv Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9012-9540","authenticated-orcid":false,"given":"Ranel","family":"Loutati","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Soroka University Medical Center, Faculty of Health Sciences Ben Gurion University of The Negev  Be'er Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Caspi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Tel Aviv Sourasky University Medical Center (Ichilov)  Tel Aviv Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9329-3639","authenticated-orcid":false,"given":"Ori","family":"Elkayam","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Tel Aviv Sourasky University Medical Center (Ichilov)  Tel Aviv Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7031-6498","authenticated-orcid":false,"given":"Ran","family":"Abuhasira","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Soroka University Medical Center, Faculty of Health Sciences Ben Gurion University of The Negev  Be'er Sheva Israel"},{"name":"Massachusetts General Hospital  Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2894-4033","authenticated-orcid":false,"given":"Tali","family":"Eviatar","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Tel Aviv Sourasky University Medical Center (Ichilov)  Tel Aviv Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv 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