{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:39:26Z","timestamp":1792546766359,"version":"4.5.0"},"reference-count":0,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Extent of uveitis risk in juvenile idiopathic arthritis (JIA) is based on clinical factors. We aim to compare the trajectories of tear\u2010based biomarker levels of patients with JIA with and without uveitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective multicenter study included children with JIA at risk for uveitis (JIA\u2010no\u2010U), and with JIA\u2010associated uveitis (JIA\u2010U). Serial tear samples were collected from each eye by Schirmer strips at enrollment (E) and follow\u2010up (FU1, FU2). S100 proteins, cytokines, and chemokines were assayed by Luminex or ELISA and compared between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Fifty patients (37 JIA\u2010no\u2010U, 13 JIA\u2010U) contributed 222 samples (150 JIA\u2010no\u2010U, 73 JIA\u2010U). At E there were no significant differences in biomarker levels between JIA\u2010U and JIA\u2010no\u2010U. During follow\u2010up of JIA\u2010U, monocyte chemoattractant protein\u20101 (MCP\u20101) levels increased longitudinally from E to FU1 and FU2 (1.63\u00b10.31 to 2.46\u00b10.31, p=0.005; and 2.89\u00b10.32, p&lt;0.0001), similar in Chemokine (C\u2010X\u2010C motif) Ligand (CXCL)\u201010 from E to FU1 and FU2 (4.39\u00b10.41 to 5.26\u00b10.41, p = 0.030; and 6.51\u00b10.43, p &lt; 0.0001) and in IL\u20108 levels from E to FU1 and FU2 (3.09\u00b10.30 to 4.25\u00b10.30, p = 0.006; and 4.65\u00b10.32, p \u2264 0.001). In both groups, S100A12 and S100A8\/A9 increased from E to FU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Longitudinal changes in MCP\u20101, CXCL10 and IL\u20108 levels in tear fluid in JIA\u2010U may reflect inflammatory ocular processes and support the role of monocytes and interferon related pathways in uveitis. Lack of differences in S100 proteins may reflect systemic inflammation from arthritis. Tear\u2010based biomarkers may support clinical factors for identifying children with JIA who develop uveitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.80192","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:22:01Z","timestamp":1792545721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tear\u2010based biomarker trajectories associated with uveitis in juvenile idiopathic arthritis: a multicenter prospective study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6418-3254","authenticated-orcid":false,"given":"Ilaria","family":"Macorra","sequence":"first","affiliation":[{"name":"Rheumatology Unit, ERN ReCONNET Center, Meyer Children's Hospital IRCCS  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariia","family":"Pavlenko","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mekibib","family":"Altaye","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-2987","authenticated-orcid":false,"given":"Hermine I","family":"Brunner","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bohnsack","sequence":"additional","affiliation":[{"name":"University of Utah School of Medicine  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3545-8957","authenticated-orcid":false,"given":"Margaret H.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8855-845X","authenticated-orcid":false,"given":"Ashley M.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Children's Mercy Kansas City  Kansas City MO USA"},{"name":"University of Missouri\u2010Kansas City School of Medicine  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Davidson","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Duell","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9609-0546","authenticated-orcid":false,"given":"Bharti","family":"Gangwani","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital  Boston MA USA"},{"name":"Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-0010","authenticated-orcid":false,"given":"Aimee","family":"Hersh","sequence":"additional","affiliation":[{"name":"University of Utah School of Medicine  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary N.","family":"Holland","sequence":"additional","affiliation":[{"name":"UCLA Jules Stein Eye Institute  Los Angeles CA USA"},{"name":"UCLA David Geffen School of Medicine  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl D.","family":"Langefeld","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Lerman","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-3536","authenticated-orcid":false,"given":"Mindy","family":"Lo","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital  Boston MA USA"},{"name":"Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia Miraldi","family":"Utz","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-1756","authenticated-orcid":false,"given":"Sampath","family":"Prahalad","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta GA USA"},{"name":"Children's Healthcare of Atlanta  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-7051","authenticated-orcid":false,"given":"Grant","family":"Schulert","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Sproles","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Quinlan\u2010Waters","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Stahl","sequence":"additional","affiliation":[{"name":"Children's Mercy Kansas City  Kansas City MO USA"},{"name":"University of Missouri\u2010Kansas City School of Medicine  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry","family":"Thornton","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Tsui","sequence":"additional","affiliation":[{"name":"UCLA Jules Stein Eye Institute  Los Angeles CA USA"},{"name":"UCLA David Geffen School of Medicine  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9552-6464","authenticated-orcid":false,"given":"Sheila T.","family":"Angeles\u2010Han","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.80192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.80192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:22:01Z","timestamp":1792545721000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.80192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,20]]},"references-count":0,"alternative-id":["10.1002\/acr.80192"],"URL":"https:\/\/doi.org\/10.1002\/acr.80192","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,20]]},"assertion":[{"value":"2026-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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