{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:46:29Z","timestamp":1780472789803,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T00:00:00Z","timestamp":1552608000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","award":["AR070549"],"award-info":[{"award-number":["AR070549"]}],"id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","award":["R01HD089928"],"award-info":[{"award-number":["R01HD089928"]}],"id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","award":["P01 AR048929"],"award-info":[{"award-number":["P01 AR048929"]}],"id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"\n Objective<\/jats:title>\n \n Variants in the\n \n SLCO<\/jats:styled-content>\n 1B1\n <\/jats:italic>\n gene, encoding a hepatic methotrexate (\n MTX<\/jats:styled-content>\n ) transporter, affect clearance of high\u2010dose\n MTX<\/jats:styled-content>\n . We tested whether in the *14 and *15 alleles of\n \n SLCO<\/jats:styled-content>\n 1B1\n <\/jats:italic>\n influenced the response to low\u2010dose\n MTX<\/jats:styled-content>\n in juvenile idiopathic arthritis (\n JIA<\/jats:styled-content>\n ) patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The study included 310\n JIA<\/jats:styled-content>\n patients genotyped for three single nucleotide polymorphisms (\n SNP<\/jats:styled-content>\n s) in\n \n SLCO<\/jats:styled-content>\n 1B1\n <\/jats:italic>\n (rs4149056, rs2306283, and rs11045819). A patient's\n \n SLCO<\/jats:styled-content>\n 1B1\n <\/jats:italic>\n diplotype was determined by combining the\n SNP<\/jats:styled-content>\n s into the\n *1a<\/jats:italic>\n ,\n *1b<\/jats:italic>\n ,\n *4<\/jats:italic>\n ,\n *5<\/jats:italic>\n ,\n *14<\/jats:italic>\n , and\n *15<\/jats:italic>\n alleles. Number of active joints at follow\u2010up (visit closest to 6 months of treatment and prior to starting a tumor necrosis factor inhibitor) was used as the dependent variable in a negative binomial regression model that included active joint count at baseline as a covariate.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The\n \n SLCO<\/jats:styled-content>\n 1B1\n <\/jats:italic>\n *\n 14<\/jats:italic>\n allele was associated with less response to\n MTX<\/jats:styled-content>\n (P<\/jats:italic>\n = 0.024) and the\n *15<\/jats:italic>\n allele was not associated with response to\n MTX<\/jats:styled-content>\n (P<\/jats:italic>\n = 0.392).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n \n SLCO<\/jats:styled-content>\n 1B1\n <\/jats:italic>\n alleles may be associated with poor response to\n MTX<\/jats:styled-content>\n in\n JIA<\/jats:styled-content>\n patients. The\n *14<\/jats:italic>\n allele has been associated with fast clearance (low exposure) after high\u2010dose\n MTX<\/jats:styled-content>\n in patients with leukemia. Thus, the\n \n SLCO<\/jats:styled-content>\n 1B1\n <\/jats:italic>\n gene may be informative for precision dosing of\n MTX<\/jats:styled-content>\n in\n JIA<\/jats:styled-content>\n patients. Patients carrying the\n *14<\/jats:italic>\n allele may require a higher dose than noncarriers to achieve a similar response to\n MTX<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acr2.1008","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T07:26:16Z","timestamp":1552634776000},"page":"58-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of\n \n SLCO<\/scp>\n 1B1\n <\/i>\n *14 Allele with Poor Response to Methotrexate in Juvenile Idiopathic Arthritis Patients"],"prefix":"10.1002","volume":"1","author":[{"given":"Laura B.","family":"Ramsey","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Cincinnati Cincinnati Ohio"},{"name":"Division of Research in Patient Services Cincinnati Children\u2019s Hospital Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halima","family":"Moncrieffe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati Cincinnati Ohio"},{"name":"Center for Autoimmune Genetics & Etiology Cincinnati Children\u2019s Hospital Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsey N.","family":"Smith","sequence":"additional","affiliation":[{"name":"Children\u2019s Mercy Kansas City and the University of Kansas Medical Center Kansas City Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Sudman","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Genetics & Etiology Cincinnati Children\u2019s Hospital Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda C.","family":"Marion","sequence":"additional","affiliation":[{"name":"Center for Public Health Genomics and Department of Biostatistical Sciences Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl\u00a0D.","family":"Langefeld","sequence":"additional","affiliation":[{"name":"Center for Public Health Genomics and Department of Biostatistical Sciences Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara L.","family":"Becker","sequence":"additional","affiliation":[{"name":"Children\u2019s Mercy Kansas City and the University of Kansas Medical Center Kansas City Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan D.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati Cincinnati Ohio"},{"name":"Center for Autoimmune Genetics & Etiology Cincinnati Children\u2019s Hospital Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-6581-4.10013-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20460"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34343"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.129668.111"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-452839"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2014.125"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex206"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40216"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.9.1.19"},{"key":"e_1_2_6_11_1","article-title":"Toward new classification criteria for juvenile idiopathic 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