{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T05:31:55Z","timestamp":1768800715391,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["5R01AR057781\u201004"],"award-info":[{"award-number":["5R01AR057781\u201004"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"Objective<\/jats:title>Our aim was to identify cytokines and chemokines in patients with adult dermatomyositis (DM<\/jats:styled-content>) and juvenile dermatomyositis (JDM<\/jats:styled-content>) that predict changes in disease activity.<\/jats:p><\/jats:sec>Methods<\/jats:title>Multiplexed immunoassays (Meso Scale Discovery) enabled simultaneous measurement of interferon (IFN<\/jats:styled-content>)\u2010regulated chemokines and other pro\u2010 and anti\u2010inflammatory cytokines specific to differentiation of specific T\u2010cell and innate pathways. Cytokine scores were computed for IFNCK<\/jats:styled-content> (IP<\/jats:styled-content>\u201010, MCP<\/jats:styled-content>\u20101), Th1 (IFN<\/jats:styled-content>\u0263, TNF<\/jats:styled-content>\u03b1, and IL<\/jats:styled-content>2), Th2 (IL<\/jats:styled-content>4, IL<\/jats:styled-content>10, IL<\/jats:styled-content>12, and IL<\/jats:styled-content> 13), Th17 (IL<\/jats:styled-content>6, IL<\/jats:styled-content>17, IL<\/jats:styled-content>1\u03b2), macrophage (MIP<\/jats:styled-content>\u20101\u03b1, MIP<\/jats:styled-content>\u20101\u03b2, IL<\/jats:styled-content>8), and regulatory (IL<\/jats:styled-content>10, TNF<\/jats:styled-content>\u03b1) factors. Spearman correlation and mixed models were used to examine whether cytokines at a previous visit predict change in disease activity at the next visit.<\/jats:p><\/jats:sec>Results<\/jats:title>The study included 36 patients (16 DM<\/jats:styled-content> and 20 JDM<\/jats:styled-content>) with at least two visits (87 patient intervals between two visits). Mean age (SD<\/jats:styled-content>) at inclusion was 56.9 (18.4) years for DM<\/jats:styled-content> and 10.8 (6.6) years in JDM<\/jats:styled-content>, 67% of patients were female, 89% Caucasian. The mean (SD<\/jats:styled-content>) physician global, muscle and extra\u2010muscular disease activity Visual Analog Scale scores at inclusion were 41 (26), 36 (30), and 34 (21) mm, respectively. The change in IFN<\/jats:styled-content> score from one visit to the next was associated with the change in physician global (P<\/jats:italic> = 0.010) and extramuscular (P<\/jats:italic> < 0.001) disease activity scores. Preliminary results revealed significant correlations of previous IFNCK<\/jats:styled-content> score and IL<\/jats:styled-content>\u20106 with subsequent disease activity measures, but after adjustment for multiple visits per patient, these associations did not reach statistical significance.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>There is a potential relationship between IFNCK<\/jats:styled-content> and other cytokine scores seen in adult and juvenile DM<\/jats:styled-content> with future disease states.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.1011","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T23:34:17Z","timestamp":1555025657000},"page":"83-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Interferon Chemokine Score and Other Cytokine Measures Track With Changes in Disease Activity in Patients With Juvenile and Adult Dermatomyositis"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5847-7475","authenticated-orcid":false,"given":"Cynthia S.","family":"Crowson","sequence":"first","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly S.","family":"Hein","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard S.","family":"Pendegraft","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Strausbauch","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy 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