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Potential predictors of reduced grip force (less than 50% of expected) at 5 years were examined using logistic regression. Differences in percentage of expected grip force values over the study period and differences in change over time, by baseline disease parameters, were estimated using mixed linear\u2010effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 200 patients with early <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, 44% had reduced grip force 5 years after diagnosis. Baseline characteristics that predicted reduced grip force at 5 years included high scores for the Health Assessment Questionnaire Disability Index (odds ratio 1.54 per <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>; 95% confidence interval 1.13\u20102.11), high scores for pain and patient global assessment, and low grip force. C\u2010reactive protein levels, the erythrocyte sedimentation rate, the 28\u2010joint Disease Activity Score (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28), rheumatoid factor, anti\u2013cyclic citrullinated peptide antibodies, joint counts, and synovitis of individual joints in the dominant upper extremity did not predict reduced grip force. Patients with baseline synovitis of the wrist or metacarpophalangeal joints or patients with a high <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 had lower estimated grip force at inclusion but also greater improvement of grip force over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patient\u2010reported outcomes predicted reduced grip strength 5 years after diagnosis. This underlines the prognostic importance of disability in early <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>. Joint counts and synovitis in individual joints may change rapidly in early <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and appear to be less predictive of long\u2010term hand function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.11062","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T07:03:30Z","timestamp":1566198210000},"page":"507-515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Relation Between Disease Activity, Patient\u2010Reported Outcomes, and Grip Force Over Time in Early Rheumatoid Arthritis"],"prefix":"10.1002","volume":"1","author":[{"given":"Maria","family":"Rydholm","sequence":"first","affiliation":[{"name":"Lund University and Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingegerd","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[{"name":"Lund University and Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Hagel","sequence":"additional","affiliation":[{"name":"Lund University and Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart T. 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