{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:24:56Z","timestamp":1779333896773,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This multicenter incident cohort aimed to characterize how often early rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>) patients self\u2010report episodic joint inflammation (palindromic rheumatism) preceding <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> diagnosis and which characteristics differentiate these patients from those without prior episodic symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were from patients with early confirmed or suspected <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> (more than 6 weeks and less than 12 months) enrolled in the Canadian Early ArThritis CoHort (<jats:styled-content style=\"fixed-case\">CATCH<\/jats:styled-content>) between April 2017 to March 2018 who completed study case report forms assessing joint pain and swelling prior to <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> diagnosis. Chi\u2010square and <jats:italic>t<\/jats:italic> tests were used to compare characteristics of patients with and without self\u2010reported episodic joint inflammation prior to <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> diagnosis. Multivariable logistic regression was used to identify sociodemographic and clinical measures associated with past episodic joint inflammation around the time of <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 154 <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> patients were included; 66% were female, and mean (SD) age and <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> symptom duration were 54 (15) years and 141 (118) days. Sixty\u2010five (42%) <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> patients reported a history of episodic joint pain and swelling, half of whom reported that these symptoms preceded <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> diagnosis by over 6 months. <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> patients with past episodic joint inflammation were more often female, had higher income, were seropositive, had more comorbidities, fewer swollen joints, and lower Clinical Disease Activity Index (<jats:styled-content style=\"fixed-case\">CDAI<\/jats:styled-content>) around the time of <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> diagnosis (<jats:italic>P<\/jats:italic> &lt; 0.05). These associations remained significant in multivariable regression adjusting for other sociodemographic and <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> clinical measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Almost half of <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> patients experienced episodic joint inflammation prior to <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> diagnosis. These patients were more often female, had higher income, and presented with milder disease activity at <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.11086","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T04:49:49Z","timestamp":1571633389000},"page":"614-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Palindromic Rheumatism Frequently Precedes Early Rheumatoid Arthritis: Results From an Incident Cohort"],"prefix":"10.1002","volume":"1","author":[{"given":"L.","family":"Ellingwood","sequence":"first","affiliation":[{"name":"University of Western Ontario London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Schieir","sequence":"additional","affiliation":[{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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