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Inclusion criteria consisted of studies that investigated <jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content> in adults with respective <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>s. Studies were excluded if a complete manuscript was not written in English or was a case report.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one studies were included (27 with healthy age\u2010\/gender\u2010matched control group for comparison and 4 without). <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>s analyzed in articles with control group: 11 rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>), 14 systemic lupus erythematosus (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>), 4 systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c), 1 idiopathic inflammatory myopathies (<jats:styled-content style=\"fixed-case\">IIM<\/jats:styled-content>), 1 Takayasu arteritis, and 1 psoriasis. Nine out of 11 <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> studies, 12 out of 14 <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> studies, and 2 out of 4 <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c studies showed statistically significant increased <jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content> when compared with the control group. <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>s analyzed in studies without control group: two Kawasaki disease, one juvenile idiopathic arthritis (<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>), and one antiphospholipid syndrome (<jats:styled-content style=\"fixed-case\">APS<\/jats:styled-content>) article, which demonstrated increased coronary arterial calcium burden, however, without statistically significant data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>s, especially <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, are associated with higher <jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content> compared with the control group, indicating increased risk of coronary atherosclerosis. Our search did not elicit sufficient publications or statistically significant results in many other <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.11107","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T07:27:13Z","timestamp":1578295633000},"page":"84-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Utility of Coronary Calcium Scoring (<scp>CCS<\/scp>) in Connective Tissue Disorders (<scp>CTD<\/scp>s) for the Evaluation of Subclinical Coronary Atherosclerosis \u2013 A Systematic Review"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4092-1878","authenticated-orcid":false,"given":"Sohail","family":"Farshad","sequence":"first","affiliation":[{"name":"Beaumont Health System Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1805-992X","authenticated-orcid":false,"given":"Alexandra","family":"Halalau","sequence":"additional","affiliation":[{"name":"Beaumont Health System, Royal Oak, Michigan, and Oakland University William Beaumont School of Medicine Rochester Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"Townsend","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Schiopu","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043430"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000174800.78362.ec"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken395"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24537"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311279"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437741.48606.98"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20303"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.12.1285"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90282-T"},{"key":"e_1_2_7_12_1","unstructured":"WellsGA SheaB O'ConnellD PetersonJ WelchV LososM et al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta\u2010analyses. 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