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Joint models were created to evaluate the course of PROs over 2 years. The difference in PRO scores from baseline to 24 months was measured, and the percentage of patients meeting the minimum clinically important difference (MCID) was calculated. Correlations between PROs and SSc\u2010ILD disease severity measures were also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with CYC and MMF led to improvements in several PROs with no between\u2010treatment differences. Scores for the Transitional Dyspnea Index (TDI) and St. George\u2019s Respiratory Questionnaire (SGRQ) improved significantly over 2 years, and 29%\/24% and 28%\/25% of participants in the CYC\/MMF groups met or exceeded the MCID estimates for TDI and SGRQ, respectively. At baseline, the forced vital capacity (FVC) percentage predicted (FVC%\u2010predicted) did not correlate with the Baseline Dyspnea Index or SGRQ. However, improvements in the FVC%\u2010predicted were weakly associated with improvements in dyspnea (assessed by the TDI) and SGRQ scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment with CYC and MMF improved overall health\u2010related quality of life in patients with SSc\u2010ILD. The relationship between PRO measures and the FVC was relatively weak, suggesting that PROs provide complementary information about treatment efficacy not captured by changes in the FVC alone in this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.11125","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T10:02:57Z","timestamp":1589968977000},"page":"362-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Treatment With Mycophenolate and Cyclophosphamide Leads to Clinically Meaningful Improvements in Patient\u2010Reported Outcomes in Scleroderma Lung Disease: Results of Scleroderma Lung Study II"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3750-6569","authenticated-orcid":false,"given":"Elizabeth R.","family":"Volkmann","sequence":"first","affiliation":[{"name":"University of California Los 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