{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:52:04Z","timestamp":1759452724000,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Current evidence highlights a link between insulin resistance (IR) and disease activity in rheumatoid arthritis (RA), suggesting that insulin sensitivity can be improved by treating patients with TNF\u2010\u03b1 blockers. Although reduced IR has been shown in RA patients who receive monoclonal antibody treatment, the efficacy remains to be elucidated when using recombinant soluble receptor fusion proteins. In particular, etanercept (ETA) is capable of blocking lymphotoxin\u2010\u03b1, a cytokine\u2010related to IR\u2010associated disease status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was carried out in nondiabetic active RA patients receiving a 25\u2010mg subcutaneous ETA injection twice weekly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients aged 31 to 73 years (50.9 \u00b1 10.6), na\u00efve to biological and targeted synthetic disease\u2010modifying antirheumatic drugs with DAS28 scores of 5.17 to 7.49 (6.11 \u00b1 0.66), were classified into high\u2010IR and low\u2010IR groups based on their baseline homeostatic model assessment (HOMA)\u2010IR levels. No differences were found between the two groups in terms of age, sex, weight, body mass index, seropositivity, and medication profiles before the injection. After a 24\u2010week therapeutic period, there were reduced HOMA\u2010IR levels in all patients in the high\u2010IR group (3.390 \u00b1 0.636 to 2.234 \u00b1 0.870, <jats:italic>P<\/jats:italic> &lt; 0.001). A greater decrease in DAS28 values was found in patients with reduced IR than those without a reduction (2.54 \u00b1 0.67 versus 1.46 \u00b1 0.46, <jats:italic>P<\/jats:italic> = 0.006) in the low\u2010IR group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed an improvement in insulin sensitivity in nondiabetic active RA patients following 24\u2010week recombinant soluble TNF\u2010\u03b1 receptor fusion protein therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.11157","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T08:18:26Z","timestamp":1591949906000},"page":"401-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Recombinant Soluble TNF\u2010\u03b1 Receptor Fusion Protein Therapy Reduces Insulin Resistance in Non\u2010Diabetic Active Rheumatoid Arthritis Patients"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9881-7024","authenticated-orcid":false,"given":"Chrong\u2010Reen","family":"Wang","sequence":"first","affiliation":[{"name":"National Cheng Kung University Hospital Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Hospital Tainan 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