{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:26:00Z","timestamp":1793179560484,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006356","name":"Syddansk Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004196","name":"Odense Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To define the proportions of agreement between fluorine\u201018\u2010fluorodeoxyglucose (18F\u2010FDG) positron emission tomography\/computed tomography (PET\/CT), clinical diagnosis, and temporal artery biopsy (TAB) in patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). Furthermore, the association of 18F\u2010FDG PET\/CT uptake patterns and clinical presentation of newly diagnosed PMR and GCA was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty patients newly suspected of having PMR, GCA, or concomitant PMR and GCA were included and followed for 40 weeks. Every patient underwent an 18F\u2010FDG PET\/CT scan before or within 3 days of initiation of steroids in case of GCA. FDG uptakes in 8 paired articular\/periarticular sites and 14 arterial segments were evaluated based on a 4\u2010point visual grading scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 80 patients (female: 50 [62.5%]; mean age \u00b1 SD: 72.0 \u00b1 7.9), 64 (80.0%) patients were diagnosed with pure PMR, 3 (3.7%) with pure GCA, and 10 (12.5%) with concomitant PMR and GCA. Additionally, three (3.7%) patients were diagnosed with seronegative rheumatoid arthritis during the follow\u2010up period. For the diagnosis of PMR, 18F\u2010FDG PET\/CT had a proportion of agreement of 75.3 (64.2\u201084.4), compared with clinical diagnosis. When comparing findings of 18F\u2010FDG PET\/CT with TAB, 18F\u2010FDG PET\/CT had a proportion of agreement of 93.0 (84.3\u201097.7) in all included patients and 69.2 (38.6\u201090.9) in the subgroup of patients with vasculitis. C\u2010reactive protein was significantly higher in patients with PMR activity on 18F\u2010FDG PET\/CT compared with those without 18F\u2010FDG PET\/CT activity (<jats:italic>P<\/jats:italic> value = 0.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>18F\u2010FDG PET\/CT is a powerful imaging technique in PMR and GCA that was in good agreement with clinical diagnosis and TAB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.11163","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T10:24:18Z","timestamp":1595413458000},"page":"478-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The Utility of 18F\u2010FDG PET\/CT in Patients With Clinical Suspicion of Polymyalgia Rheumatica and Giant Cell Arteritis: A Prospective, Observational, and Cross\u2010sectional 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