{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:19:12Z","timestamp":1789705152522,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["Postgraduate scholarship"],"award-info":[{"award-number":["Postgraduate scholarship"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The study objective was to compare incident cancer rates among patients with anti\u2010neutrophil cytoplasm antibody\u2010associated vasculitis (AAV) and polyarteritis nodosa (PAN) in Western Australia (WA) with the general population and perform time\u2010varying analyses to identify periods with greatest excess cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Administrative health data from patients hospitalized with incident AAV\/PAN from 1980 to 2014 were linked to the WA cancer registry, which holds compulsorily reported cancer data (excluding skin squamous cell and basal cell carcinomas). Incident cancer rates in patients with AAV\/PAN were compared with age\u2010, sex\u2010, and calendar\u2010year\u2010matched WA population rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with AAV\/PAN had higher overall rates of incident cancer compared with the matched population (standardized incidence ratio [SIR], 1.74; 95% confidence interval [CI], 1.42\u20102.10). In subgroup analyses, incident cancer rates in patients with granulomatosis with polyangiitis\/eosinophilic granulomatosis with polyangiitis were approximately double the general population (SIR, 2.21; 95% CI, 1.73\u20102.78) but similar to the general population in patients with microscopic polyangiitis\/PAN (SIR, 1.21; 95% CI, 0.85\u20101.68). Patients with AAV\/PAN had higher rates of genitourinary, skin, hematological, and lung cancers. Excess rates of hematological and lung cancers peaked early after diagnosis, whereas excess skin and genitourinary cancer rates peaked at 5 and 10\u2009years, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the importance of long\u2010term cancer surveillance in patients with AAV\/PAN and defines time frames of excess risk for specific cancers, which may help inform guidance on cancer screening. Furthermore, it indicates the need for skin surveillance for melanoma in addition to nonmelanoma skin cancers in patients who have greater environmental ultraviolet exposure, such as in Australia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.11378","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:15:20Z","timestamp":1638922520000},"page":"223-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cancer in <scp>Anti\u2010Neutrophil<\/scp> Cytoplasm <scp>Antibody\u2010Associated<\/scp> Vasculitis and Polyarteritis Nodosa in Australia: A <scp>Population\u2010Based<\/scp> Study"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2975-176X","authenticated-orcid":false,"given":"Joanna","family":"Tieu","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide Australia"},{"name":"Rheumatology 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