{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:54:47Z","timestamp":1787500487440,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013018","name":"Hospital for Special Surgery","doi-asserted-by":"publisher","award":["Michael D. Lockshin Fellowship from the Barbara Volcker Center for Women and Rheumatic Diseases"],"award-info":[{"award-number":["Michael D. Lockshin Fellowship from the Barbara Volcker Center for Women and Rheumatic Diseases"]}],"id":[{"id":"10.13039\/100013018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K23AR068449"],"award-info":[{"award-number":["K23AR068449"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30AR072583"],"award-info":[{"award-number":["P30AR072583"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","award":["Scientist Development Award"],"award-info":[{"award-number":["Scientist Development Award"]}],"id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007273","name":"Weill Cornell Medical College","doi-asserted-by":"publisher","award":["Seed Grant for Innovative Primary Care"],"award-info":[{"award-number":["Seed Grant for Innovative Primary Care"]}],"id":[{"id":"10.13039\/100007273","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Frailty is associated with disability and mortality independent of age. Although studies have evaluated frailty in rheumatoid arthritis (RA), information on the prevalence of frailty in ankylosing spondylitis (AS) and psoriatic arthritis (PsA) is limited. We aimed to determine the prevalence of frailty in AS and PsA and to evaluate whether characteristics known to be associated with frailty, including anxiety, differ among these three types of inflammatory arthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a cross sectional study of Centers for Medicare &amp; Medicaid Services (CMS) beneficiaries aged 65\u2009years or older with AS, PsA, or RA enrolled in 2014. We operationalized frailty using a validated claims\u2010based frailty index. We also explored the prevalence of frailty among CMS beneficiaries younger than age 65\u2009years with work disability, a younger population that also may be at risk of frailty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of frailty in beneficiaries aged 65\u2009years or older with AS and PsA was 45.2% and 46.7%, respectively, significantly lower than in RA (65.9%,\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u00a00.05). The prevalence of frailty in beneficiaries less than 65\u2009years old was much lower overall, though still highest in RA; 11.7%, 4.4%, and 7.0% in RA, AS, and PsA, respectively (\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u00a00.05). Anxiety was significantly associated with frailty in subjects of all ages, particularly among those less than 65\u2009years old (\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Almost half of beneficiaries with AS or PsA aged 65\u2009years old or older were frail, higher than in younger disabled beneficiaries. Further studies are needed to understand the risks of developing frailty in these diseases. Frailty was associated with anxiety, particularly in the younger age groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr2.11388","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T02:36:41Z","timestamp":1641436601000},"page":"300-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence of Frailty in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis: Data from a National Claims Dataset"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6176-9740","authenticated-orcid":false,"given":"Sarah B.","family":"Lieber","sequence":"first","affiliation":[{"name":"Hospital for Special Surgery  New York New York"},{"name":"Weill Cornell Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9540-6614","authenticated-orcid":false,"given":"Iris","family":"Navarro\u2010Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery  New York New York"},{"name":"Weill Cornell Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangala","family":"Rajan","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8907-8976","authenticated-orcid":false,"given":"Jeffrey R.","family":"Curtis","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-6828","authenticated-orcid":false,"given":"Sebastian E.","family":"Sattui","sequence":"additional","affiliation":[{"name":"University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geyanne","family":"Lui","sequence":"additional","affiliation":[{"name":"New York Institute of Technology College of Osteopathic Medicine  Old Westbury New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Schwartzman","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery  New York New York"},{"name":"Weill Cornell Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6085-8664","authenticated-orcid":false,"given":"Lisa A.","family":"Mandl","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery  New York New York"},{"name":"Weill Cornell Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.3.262"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2015.01.016"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3541-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23468"},{"key":"e_1_2_6_6_1","article-title":"Frailty and sarcopenia in inflammatory rheumatic disease. Arthritis","volume":"71","author":"Trujillo E","year":"2019","journal-title":"Rheumatol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000729"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610211002110"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igy023.2662"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12709"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(92)90133-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24747"},{"key":"e_1_2_6_13_1","first-page":"585","article-title":"Frailty in seropositive rheumatoid arthritis patients of working age: a cross\u2010sectional study","volume":"37","author":"Haider S","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_14_1","first-page":"488","article-title":"The Comprehensive Rheumatologic Assessment of Frailty (CRAF): development and validation of a multidimensional frailty screening tool in patients with rheumatoid arthritis","volume":"38","author":"Salaffi F","year":"2020","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.14283\/jfa.2020.1","article-title":"Clinical characteristics of frailty in Japanese rheumatoid arthritis patients","volume":"9","author":"Yoshii I","year":"2020","journal-title":"J Frailty Aging"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14110"},{"key":"e_1_2_6_17_1","unstructured":"Medicare\u2010Medicaid Linked Enrollee Analytic Data Source Public Use File.Centers for Medicare & Medicaid Services.2017. 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