{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:41:17Z","timestamp":1764175277711,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The rationale for this study was based on reports that valosin\u2010containing protein (VCP) mutations are found in hereditary inclusion body myositis (IBM) and VCP was detected in rimmed vacuoles of sporadic IBM (sIBM) muscle biopsies. Autoantibodies to VCP have not been reported in sIBM or other inflammatory myopathies (IIMs). The aim of this study was to determine the frequency and clinical significance of anti\u2010VCP antibodies in sIBM and other IIMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sera were collected from 73 patients with sIBM and 383 comparators or controls, including patients with IIM (n\u00a0=\u00a069), those with juvenile dermatomyositis (JDM) (n\u00a0=\u00a067), those with juvenile idiopathic arthritis (JIA) (n\u00a0=\u00a047), those with primary biliary cholangitis (PBC) (n\u00a0=\u00a0105), controls that were age matched to patients with sIBM (similarly aged controls [SACs]) (n\u00a0=\u00a063), and healthy controls (HCs) (n\u00a0=\u00a032).\u00a0Immunoglobulin G antibodies to VCP were detected by addressable laser bead immunoassay using a full\u2010length recombinant human protein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among patients with sIBM, 26.0% (19\/73) were positive for anti\u2010VCP. The frequency in disease controls was 15.0% (48\/320). Among SACs, the frequency was 1.6% (1\/63), and in HCs 0% (0\/32). Frequencies were 17.5% (11\/63) for IIM, 25.7% (27\/105) for PBC, 3.0% (2\/67) for JDM, and 17.0% (8\/47) for JIA. The sensitivity, specificity, positive predictive value, and negative predictive value of anti\u2010VCP for sIBM were 26.0%, 87.2%, 28.4%, and 85.9%, respectively. Of patients with sIBM, 15.1% (11\/73) were positive for both anti\u2010VCP and anti\u2013cytosolic 5\u2032\u2010nucleotidase 1A (NT5c1A). Eleven percent of patients (8\/73) were positive for anti\u2010VCP, but negative for anti\u2010NT5c1A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010VCP has low sensitivity and moderate specificity for sIBM but may help fill the seronegative gap in sIBM. Further studies are needed to determine whether anti\u2010VCP is a biomarker for a clinical phenotype that may have clinical value.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.11510","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T04:01:38Z","timestamp":1668398498000},"page":"10-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anti\u2013<scp>Valosin\u2010Containing<\/scp> Protein (<scp>VCP<\/scp>\/p97) Autoantibodies in Inclusion Body Myositis and Other Inflammatory Myopathies"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4911-4925","authenticated-orcid":false,"given":"Adam","family":"Amlani","sequence":"first","affiliation":[{"name":"Cumming School of Medicine, University of Calgary  Alberta 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