{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:18:11Z","timestamp":1785251891381,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100003284","name":"Pulmonary Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003284","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K08HL165106"],"award-info":[{"award-number":["K08HL165106"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI68299"],"award-info":[{"award-number":["R01AI68299"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI137249"],"award-info":[{"award-number":["R01AI137249"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5T32AI007090\u201044"],"award-info":[{"award-number":["5T32AI007090\u201044"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5U19AI16"],"award-info":[{"award-number":["5U19AI16"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Interstitial lung diseases (ILDs) are a heterogeneous group of disorders that can develop in patients with connective tissue diseases. Establishing autoimmunity in ILD impacts prognosis and treatment. Patients with ILD are screened for autoimmunity by measuring antinuclear autoantibodies, rheumatoid factors, and other nonspecific tests. However, this approach may miss autoimmunity that manifests as autoantibodies to tissue antigens not previously defined in ILD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We use Phage Immunoprecipitation\u2010Sequencing (PhIP\u2010Seq) to conduct an autoantibody discovery screen of patients with ILD and controls. We screened for novel autoantigen candidates using PhIP\u2010Seq. We next developed a radio\u2010labeled binding assay and validated the leading candidate in 398 patients with ILD recruited from two academic medical centers and 138 blood bank individuals that formed our reference cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PhIP\u2010Seq identified 17 novel autoreactive targets, and machine learning classifiers derived from these targets discriminated ILD serum from controls. Among the 17 candidates, we validated CDHR5 and found CDHR5 autoantibodies in patients with rheumatologic disorders and importantly, patients not previously diagnosed with autoimmunity. Using survival and transplant free\u2013survival data available from one of the two centers, patients with CDHR5 autoantibodies showed worse survival compared with other patients with connective tissue disease ILD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We used PhIP\u2010Seq to define a novel CDHR5 autoantibody in a subset of select patients with ILD. Our data complement a recent study showing polymorphisms in the CDHR5\u2010IRF7 gene locus strongly associated with titer of anticentromere antibodies in systemic sclerosis, creating a growing body of evidence suggesting a link between CDHR5 and autoimmunity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.11696","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T01:21:25Z","timestamp":1719883285000},"page":"568-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Phage Immunoprecipitation\u2010Sequencing Reveals <scp>CDHR5<\/scp> Autoantibodies in Select Patients With Interstitial Lung Disease"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7652-1043","authenticated-orcid":false,"given":"Vaibhav","family":"Upadhyay","sequence":"first","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young me","family":"Yoon","sequence":"additional","affiliation":[{"name":"University of Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E.","family":"Vazquez","sequence":"additional","affiliation":[{"name":"University of California San Francisco and Chan Zuckerberg Biohub"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania E.","family":"Velez","sequence":"additional","affiliation":[{"name":"University of Chicago, Illinois, and University of Virginia  Charlottesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk D.","family":"Jones","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathryn T.","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Law","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Wolters","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seoyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2693-3648","authenticated-orcid":false,"given":"Monica M.","family":"Yang","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Farrand","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imre","family":"Noth","sequence":"additional","affiliation":[{"name":"University of Virginia  Charlottesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Strek","sequence":"additional","affiliation":[{"name":"University of Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"DeRisi","sequence":"additional","affiliation":[{"name":"University of California San Francisco and Chan Zuckerberg Biohub"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne I.","family":"Sperling","sequence":"additional","affiliation":[{"name":"University of Chicago, Illinois, and University of Virginia  Charlottesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-4802","authenticated-orcid":false,"given":"Anthony K.","family":"Shum","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202204-0781OC"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01052-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211138"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1255ST"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201808-565CME"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.06.009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00150-2015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2662"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200702-220OC"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-02103-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202201-0011OC"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd4585"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210554"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abh2624"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816721"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.55053"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.78550"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1856"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21-1172"},{"key":"e_1_2_7_21_1","first-page":"8","article-title":"Autoantigen profiling reveals a shared post\u2010COVID signature in fully recovered and long COVID patients","author":"Bodansky A","year":"2023","journal-title":"JCI Insight"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.04.017"},{"key":"e_1_2_7_23_1","article-title":"Antigenic responses are hallmarks of fibrotic interstitial lung diseases independent of underlying etiologies","author":"Yoon YM","year":"2023","journal-title":"medRxiv"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006998"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26603-2"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00646-2019"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-204596"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0204OC"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00069.2014"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218918"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202005-2032ST"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0143-2019"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.03.044"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)30033-9"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24621"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.773352"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav5597"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2018.03.002"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400909"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20507"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.067"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.02.031"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.11.020"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.135791"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00451.2020"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02441-2018"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02373-2021"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1983"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201712-2410OC"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1972"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12760-y"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.2147\/OARRR.S50009"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/psc.1166"}],"container-title":["ACR Open Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr2.11696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:16:57Z","timestamp":1759418217000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr2.11696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":54,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/acr2.11696"],"URL":"https:\/\/doi.org\/10.1002\/acr2.11696","archive":["Portico"],"relation":{},"ISSN":["2578-5745","2578-5745"],"issn-type":[{"value":"2578-5745","type":"print"},{"value":"2578-5745","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2023-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}