{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:52:37Z","timestamp":1759452757990,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["U54 AR057319"],"award-info":[{"award-number":["U54 AR057319"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ACR Open Rheumatology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Signal regulatory protein \u03b1 (SIRP\u03b1) is found primarily on myeloid cells, including macrophages and neutrophils; binds to CD47; and regulates phagocytosis, antigen presentation, cellular fusion, cell proliferation, and migration. Therefore, SIRP\u03b1 may be involved in the pathogenesis of autoimmune diseases, including systemic vasculitis. This study aimed to assess SIRP\u03b1 expression in tissue samples from patients with vasculitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunohistochemical staining for SIRP\u03b1 was performed on temporal artery (TA), kidney, and lung biopsy samples from patients with giant cell arteritis (GCA), patients with microscopic polyangiitis (MPA), patients with granulomatosis with polyangiitis (GPA), and patients without vasculitis. A score of SIRP\u03b1<jats:sup>+<\/jats:sup> expression was calculated, derived from the percentages of monocytes, macrophages, and dendritic cells and neutrophils with different staining intensities in affected tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 46 samples from patients with different vasculitides (GCA, MPA, and GPA) were included in the study. Tissue samples included TA samples from 15 patients with GCA; kidney samples from 11 and 9 patients with GPA and MPA, respectively; and lung samples from 11 patients with GPA. Most tissue samples from patients with active vasculitis (15 of 15 TA samples, 17 of 20 kidney samples, and 9 of 11 lung samples) showed SIRP\u03b1 staining. SIRP\u03b1 staining intensity was less in kidney samples compared to TA and lung samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates high\u2010level expression of SIRP\u03b1 in macrophages and monocytes in affected tissue in systemic vasculitis. These findings provide a foundation for further studies exploring the role of the SIRP\u03b1\u2013CD47 pathway in the pathogenesis of systemic vasculitis and the potential for the blockade of SIRP\u03b1 and\/or the depletion of SIRP\u03b1<jats:sup>+<\/jats:sup> cells as treatment of systemic vasculitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.11716","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T01:39:05Z","timestamp":1721093945000},"page":"634-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Signal Regulatory Protein \u03b1 Expression in Systemic Vasculitis"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0903-1949","authenticated-orcid":false,"given":"Shubhasree","family":"Banerjee","sequence":"first","affiliation":[{"name":"University of Pennsylvania  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