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Using <jats:italic>International Statistical Classification of Diseases, Tenth Revision<\/jats:italic> codes, we identified individuals &gt;18 years of age who had a primary or secondary diagnosis of SLE and were hospitalized between January and June 2018. Using the validated claims\u2010based Hospital Frailty Risk Score, we categorized individuals as frail (score \u2265 5) or nonfrail (score &lt; 5) at the time of index hospitalization. Our primary outcome was readmission rates post discharge from index hospitalization. Secondary outcomes were rates of inpatient mortality and the total cost of hospitalizations. Cox proportional hazard models were used to estimate the association between frailty and risk of readmissions, with adjustment for age, sex, insurance type, household income, and Elixhauser Comorbidity Index score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 39,738 patients with SLE met eligibility criteria. Over a median follow\u2010up of eight months, frail patients with SLE (n = 18,385) had higher Elixhauser Comorbidity Index scores and longer length of stay compared to nonfrail patients with SLE (n = 21,353). Frail patients with SLE had higher readmission rates, a higher proportion of prolonged hospitalizations, and higher costs per hospitalization. Frailty was independently associated with a 10% higher risk of readmission after adjustment for covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among hospitalized adults with SLE, presence of frailty was associated with higher readmission and inpatient mortality rates. Our results highlight that frailty status can help risk stratify patients with SLE at increased risk for readmissions and other adverse health outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.11722","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T12:52:22Z","timestamp":1722257542000},"page":"700-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association Between Frailty Status and Readmissions in Hospitalized Patients With Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"6","author":[{"given":"Christopher","family":"Leung","sequence":"first","affiliation":[{"name":"Georgetown University School of Medicine  Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqas","family":"Tahir","sequence":"additional","affiliation":[{"name":"Mayo Clinic at Jacksonville  Jacksonville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenny","family":"Rosli","sequence":"additional","affiliation":[{"name":"University of Washington  Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6176-9740","authenticated-orcid":false,"given":"Sarah B.","family":"Lieber","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery and Weill Cornell Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Una E.","family":"Makris","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center  Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiha","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1328-480X","authenticated-orcid":false,"given":"Hammad","family":"Ali","sequence":"additional","affiliation":[{"name":"University of Kentucky  Lexington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-4097","authenticated-orcid":false,"given":"Radjiv","family":"Goulabchand","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de N\u00eemes and University of Montpellier  N\u00eemes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Singh","sequence":"additional","affiliation":[{"name":"University of California at San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-363X","authenticated-orcid":false,"given":"Namrata","family":"Singh","sequence":"additional","affiliation":[{"name":"University of Washington  Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/7gzsxp"},{"key":"e_1_2_6_3_1","volume-title":"Healthcare Cost and Utilization Project (HCUP) Statistical Briefs","author":"Elixhauser A","year":"2006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24900"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2012.03.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31785-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab546"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead393"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2023-001008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.14283\/jfa.2023.24"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.576134"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40859"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41144"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24504"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac001"},{"key":"e_1_2_6_17_1","unstructured":"NRD overview. 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